147729-01-9

Basic information

• Product Name: N-benzyloxycarbonyl-N-methyl-2-(5-methoxy-1-methylindolyl)amine
• CAS NO: 147729-01-9
• Molecular Weight: 324.379
• Mol File: 147729-01-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-benzyloxycarbonyl-N-methyl-2-(5-methoxy-1-methylindolyl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyloxycarbonyl-N-methyl-2-(5-methoxy-1-methylindolyl)amine(147729-01-9)
• EPA Substance Registry System: N-benzyloxycarbonyl-N-methyl-2-(5-methoxy-1-methylindolyl)amine(147729-01-9)

Safety Data

• Hazardous Substances Data: 147729-01-9(Hazardous Substances Data)

Upstream product

• 100-51-6 benzyl alcohol 
• 59908-54-2 <(5-methoxy-1-methyl)indol-2-yl>carboxylic acid 
• 147729-00-8 N-benzyloxycarbonyl-2-(5-methoxy-1-methylindolyl)amine 
• 74-88-4 methyl iodide 

Relevant articles and documents

Acetylenic and allenic derivatives of 2-(5-methoxy-1-methylindolyl) alkylamines: Synthesis and evaluation as selective inhibitors of the monoamine oxidases A and B

We report the synthesis and in vitro studies as MAO-A and MAO-B inhibitors of a new series of 2-(5-methoxy-1-methylindolyl)alkylamines, including 2-(5-methoxy-1-methylindolyl)amine 9 and its N-methyl derivative 10, 1[2-(5-methoxy-1-methylindolyl)]ethylamine 1 and its N-methyl derivative 2 and 3-[2-(5-methoxy-1-methylindolyl)propylamine 11 and its N-methyl derivative 12, so as some of the N-(2-propynyl), N-(2,3-butadienyl) and N-(2-butynyl) derivatives of 1, 2, 11 and 12 (compounds 3-8 and 13-18). All compounds were found to inhibit both MAO-A and MAO-B. Comparison with a previous series of 2-(5-methoxy-1-methylindolyl)methylamine derivatives (A1-A9) shows that in the new series, the inhibitory potency towards MAO-A generally decreases, whereas the inhibitory potency towards MAO-B generally increases, resulting in a loss of the selectivity for MAO-A seen in the reference compounds A1-A9. Structure-activity relationships are discussed.