14779-24-9Relevant articles and documents
Optimization and determination of the absolute configuration of a series of potent inhibitors of human papillomavirus type-11 E1-E2 protein-protein interaction: A combined medicinal chemistry, NMR and computational chemistry approach
Goudreau, Nathalie,Cameron, Dale R.,Deziel, Robert,Hache, Bruno,Jakalian, Araz,Malenfant, Eric,Naud, Julie,Ogilvie, William W.,O'Meara, Jeff,White, Peter W.,Yoakim, Christiane
, p. 2690 - 2700 (2007)
We have previously reported the discovery and initial SAR optimization of the first series of inhibitors of the human papillomavirus type-11 (HPV11) E1-E2 protein-protein interaction. These inhibitors featured an indandione system spiro-fused onto an all
In vivo phenotypic drug discovery: Applying a behavioral assay to the discovery and optimization of novel antipsychotic agents
Shao, Liming,Campbell, Una C.,Fang, Q. Kevin,Powell, Noel A.,Campbell, John E.,Jones, Philip G.,Hanania, Taleen,Alexandrov, Vadim,Morganstern, Irene,Sabath, Emily,Zhong, Hua M.,Large, Thomas H.,Spear, Kerry L.
supporting information, p. 1093 - 1101 (2016/07/06)
Phenotypic drug discovery (PDD) is increasingly being recognized as a viable compliment to target-based drug discovery (TDD). By measuring functional changes, typically at a systems level, PDD can facilitate the identification of compounds having a desirable pharmacology. This capability is particularly important when studying CNS diseases where drug efficacy may require modulation of multiple targets in order to overcome a robust, adaptive biological system. Here, we report the application of a mouse-based high-dimensional behavioral assay to the discovery and optimization of a structurally and mechanistically novel antipsychotic. Lead optimization focused on optimizing complex behavioral features and no explicit effort was made to identify the target (or targets) involved.
Ramoplanin derivatives possessing antibacterial activity
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Page/Page column 39; 52, (2010/11/23)
Novel ramoplanin derivatives are disclosed. These ramoplanin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against gram positive bacteria, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
