147849-60-3Relevant articles and documents
An improved reaction of tris(methylthio)methane with epoxides: Application to the efficient synthesis of β-hydroxy esters
Abood
, p. 811 - 815 (1993)
Tris(methylthio)methyllithium reacts efficiently with epoxides in THF:HMPA (5:1) at low temperature to give β-hydroxy orthotrithiocarboxylates which are converted to β-hydroxy esters in high yield.
A new class of tunable dendritic diphosphine ligands: Synthesis and applications in the Ru-catalyzed asymmetric hydrogenation of functionalized ketones
Ma, Baode,Miao, Tingting,Sun, Yihua,He, Yanmei,Liu, Ji,Feng, Yu,Chen, Hui,Fan, Qing-Hua
supporting information, p. 9969 - 9978 (2014/08/18)
A series of tunable G0-G3 dendritic 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (BINAP) ligands was prepared by attaching polyaryl ether dendrons onto the four phenyl rings on the P atoms. Their ruthenium complexes were employed in the asymmetric hydrogenation of β-ketoesters, α-ketoesters, and α-ketoamides to reveal the effects of dendron size on the catalytic properties. The second- and third-generation catalysts exhibited excellent enantioselectivities, which are remarkably higher than those obtained from the small molecular catalysts and the first-generation catalyst. Molecular modeling indicates that the incorporation of bulky dendritic wedges can influence the steric environments around the metal center. In addition, the ruthenium catalyst bearing a second-generation dendritic ligand could be recycled and reused seven times without any obvious decrease in enantioselectivity.
Organocatalytic preparation of simple β-hydroxy and β-amino esters: Low catalyst loadings and gram-scale synthesis
Jiang, Hao,Gschwend, Bjoern,Albrecht, Lukasz,Anker Jorgensen, Karl
supporting information; experimental part, p. 5052 - 5055 (2010/12/25)
A combined amino- and N-heterocyclic carbene (NHC)-catalyzed one-pot reaction sequence for the synthesis of simple enantioenriched β-hydroxy and β-amino esters using commercially available catalysts at low catalyst loadings has been developed. The desired
An improved asymmetric Reformatsky reaction mediated by (-)-N,N-dimethylaminoisoborneol
Kloetzing, Ralf J.,Thaler, Tobias,Knochel, Paul
, p. 1125 - 1128 (2007/10/03)
(-)-N,N-Dimethylaminoisoborneol ((-)-DAIB) was found to be an excellent ligand for the enantioselective addition of Reformatsky reagents to aromatic and aliphatic aldehydes. Enantioselectivities up to 93% ee were obtained with sulfur-containing aldehydes.