1480481-91-1

Basic information

• Product Name: 2-([1,1'-biphenyl]-4-ylcarboxamido)-3-chlorobenzoic acid
• Synonyms: 2-([1,1'-biphenyl]-4-ylcarboxamido)-3-chlorobenzoic acid
• CAS NO: 1480481-91-1
• Molecular Weight: 351.789
• Mol File: 1480481-91-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-([1,1'-biphenyl]-4-ylcarboxamido)-3-chlorobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-([1,1'-biphenyl]-4-ylcarboxamido)-3-chlorobenzoic acid(1480481-91-1)
• EPA Substance Registry System: 2-([1,1'-biphenyl]-4-ylcarboxamido)-3-chlorobenzoic acid(1480481-91-1)

Safety Data

• Hazardous Substances Data: 1480481-91-1(Hazardous Substances Data)

Upstream product

• 77820-58-7 methyl 3-chloroanthranilate 
• 14002-51-8 4-biphenyl-carboxylic acid chloride 

Relevant articles and documents

Discovery of novel bacterial RNA polymerase inhibitors: Pharmacophore-based virtual screening and hit optimization

The bacterial RNA polymerase (RNAP) is a validated target for broad spectrum antibiotics. However, the efficiency of drugs is reduced by resistance. To discover novel RNAP inhibitors, a pharmacophore based on the alignment of described inhibitors was used for virtual screening. In an optimization process of hit compounds, novel derivatives with improved in vitro potency were discovered. Investigations concerning the molecular mechanism of RNAP inhibition reveal that they prevent the protein-protein interaction (PPI) between σ70 and the RNAP core enzyme. Besides of reducing RNA formation, the inhibitors were shown to interfere with bacterial lipid biosynthesis. The compounds were active against Gram-positive pathogens and revealed significantly lower resistance frequencies compared to clinically used rifampicin.