1481-99-8 Usage
Description
Spiro[5.5]undecane-2,4-dione is an organic compound characterized by its unique spiro ring structure and dione functional groups. It is a key intermediate in the synthesis of various complex organic molecules and pharmaceuticals due to its versatile reactivity and structural properties.
Uses
Used in Pharmaceutical Industry:
Spiro[5.5]undecane-2,4-dione is used as a reactant for the production of hydroxy-dimethyl-oxo-cyclohexenyl-dimethyl-tetrahydro-xanthenone, which is an oral neuropeptide Y5 receptor antagonist. This application is significant because it targets the neuropeptide Y5 receptor, playing a crucial role in various physiological processes and potentially offering therapeutic benefits for conditions related to the central nervous system, such as obesity, anxiety, and depression.
Check Digit Verification of cas no
The CAS Registry Mumber 1481-99-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,8 and 1 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1481-99:
(6*1)+(5*4)+(4*8)+(3*1)+(2*9)+(1*9)=88
88 % 10 = 8
So 1481-99-8 is a valid CAS Registry Number.
InChI:InChI=1/C11H16O2/c12-9-6-10(13)8-11(7-9)4-2-1-3-5-11/h1-8H2
1481-99-8Relevant articles and documents
Synthesis and Antimalarial Properties of 1-Imino Derivatives of 7-Chloro-3-substituted-3,4-dihydro-1,9(2H,10H)-acridinediones and Related Structures
Kesten, Stephen J.,Degnan, Margaret J.,Hung, Jocelyn,McNamara, Dennis J.,Ortwine, Daniel F.,et al.
, p. 3429 - 3447 (2007/10/02)
To improve upon the activity and properties of the 3-aryl-7-chloro-3,4-dihydro-1,9(2H,10H)-acridinediones, a variety of 1-imino derivatives (3) were prepared and shown to be highly active antimalarial agents in both rodents and primates.Among structural modifications prepared, including N10-alkyl and C2-substituted analogs, removal of the C9 oxygen, and introduction of an imino side chain at C9, the imines of the N10-H acridinediones were the most active compounds obtained.The imino derivative of7-chloro-3-(2,4-dichlorophenyl)-3,4-dihydro-1,9(2H,10H)-acridinedione (9aa) proved to be highly active in advanced studies in primates.