148148-48-5Relevant articles and documents
A pharmaceutical intermediate of PROTAC molecules targeting monoacylglycerol lipase. Preparation method and application
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Paragraph 0097-0100, (2021/10/27)
The invention discloses a medical intermediate of PROTAC molecules targeting monoacylglycerol lipase, a preparation method and an application thereof, and relates to the field of medicines. It has the structure shown I: formula I. The hydroxyl end has the
Renin Inhibitors
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Page/Page column 52-53, (2010/12/29)
Disclosed are compounds having the formula (I): wherein the R1, R2, R3, X, Y, A, L, and G are defined herein. These compounds bind to aspartic proteases to inhibit their activity and are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also disclosed are methods of use of the compounds of Formula I for ameliorating or treating aspartic protease related disorders in a subject in need thereof.
RENIN INHIBITORS
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Page/Page column 159, (2008/12/04)
Disclosed are compounds of Formula (I) wherein the R, R1, R2, R3, X, Y, A, Q, E, and G are defined herein. These compounds bind to aspartic proteases to inhibit their activity and are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also disclosed are methods of use of the compounds of Formula I for ameliorating or treating aspartic protease related disorders in a subject in need thereof.