14815-19-1

Basic information

• Product Name: 2,2,2-Trifluoro-N-(3-pyridyl)acetaMide, 96%
• Synonyms: 2,2,2-Trifluoro-N-(3-pyridyl)acetaMide, 96%;2,2,2-trifluoro-N-(pyridin-3-yl)acetamide
• CAS NO: 14815-19-1
• Molecular Formula: C7H5F3N2O
• Molecular Weight: 190.1226096
• Mol File: 14815-19-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 122-126℃
• Appearance: /
• CAS DataBase Reference: 2,2,2-Trifluoro-N-(3-pyridyl)acetaMide, 96%(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-Trifluoro-N-(3-pyridyl)acetaMide, 96%(14815-19-1)
• EPA Substance Registry System: 2,2,2-Trifluoro-N-(3-pyridyl)acetaMide, 96%(14815-19-1)

Safety Data

• Hazardous Substances Data: 14815-19-1(Hazardous Substances Data)

Usage

General Description

2,2,2-Trifluoro-N-(3-pyridyl)acetamide, 96% is a chemical compound that is used in organic synthesis and pharmaceutical research. It is a white powder with a high purity of 96% and is a derivative of 3-pyridylacetic acid. 2,2,2-Trifluoro-N-(3-pyridyl)acetaMide, 96% is known for its strong electron-withdrawing properties due to the presence of three fluorine atoms and is commonly used as a building block in the synthesis of various organic molecules. It is also used as a reagent in the preparation of pharmaceutical compounds and is known for its stability and high reactivity in organic reactions.

Upstream product

• 462-08-8 pyridin-3-ylamine 
• 76-05-1 trifluoroacetic acid 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 668270-12-0 Linagliptin 
• 1673546-62-7 1-[(4-methylquinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-2,2,2-trifluoroacetylaminopiperidin-1-yl)xanthine 
• 77262-40-9 m-<(Trifluoroethyl)amino>pyridine 

Relevant articles and documents

Synthesis of Three pyridines

The synthesis of o-, m, and p-pyridine by diborane/tetrahydrofuran reduction of the corresponding trifluoroacetamide is described.The yields were 52 percent, 83 percent, and 76 percent, respectively.The synthesis, in 53 percent yield, of 2,2,2-trifluoro-N-(4-pyridyl)acetamide is also described.

ARYL SULFONAMIDES AS SMALL MOLECULE STAT3 INHIBITORS

The present disclosure provides pharmaceutical compositions comprising aryl sulfonamide Stat3 small molecule inhibitors and certain pharmaceutically acceptable salts thereof, and methods of their use for treating cancer.

The ortho and meta magnesiation of functionalized anilines and amino-substituted pyridines and pyrazines at room temperature

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A one-pot procedure for trifluoroacetylation of arylamines using trifluoroacetic acid as a trifluoroacetylating reagent

A convenient procedure for the preparation of aryl trifluoroacetamides from aryl amines is described that employs 2-4 M equiv of trifluoroacetic acid in refluxing xylene as a trifluoroacetylating agent. Addition of an amount of pyridine that is equimolar to the amount of trifluoroacetic acid present in the reaction mixture facilitates the trifluoroacetylation of rather basic arylamines.