14818-53-2

Basic information

• Product Name: Acetamide,N-(3,5-dimethylphenyl)-2,2,2-trifluoro-
• Synonyms: Acetamide,N-(3,5-dimethylphenyl)-2,2,2-trifluoro-;N-(3,5-dimethylphenyl)-2,2,2-trifluoroacetamide
• CAS NO: 14818-53-2
• Molecular Formula: C₁₀H₁₀F₃NO
• Molecular Weight: 217.19
• Mol File: 14818-53-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 83-85 °C
• Boiling Point: 258.8°Cat760mmHg
• Flash Point: 110.3°C
• Appearance: /
• Density: 1.266g/cm³
• Vapor Pressure: 0.0135mmHg at 25°C
• Refractive Index: 1.502
• PKA: 10.05±0.70(Predicted)
• CAS DataBase Reference: Acetamide,N-(3,5-dimethylphenyl)-2,2,2-trifluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide,N-(3,5-dimethylphenyl)-2,2,2-trifluoro-(14818-53-2)
• EPA Substance Registry System: Acetamide,N-(3,5-dimethylphenyl)-2,2,2-trifluoro-(14818-53-2)

Safety Data

• Hazardous Substances Data: 14818-53-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H10F3NO/c1-6-3-7(2)5-8(4-6)14-9(15)10(11,12)13/h3-5H,1-2H3,(H,14,15)

Upstream product

• 407-25-0 trifluoroacetic anhydride 
• 325142-93-6 2-(3,5-dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 108-69-0 3,5-dimethylaminoaniline 

Downstream Products

• 62351-56-8 3,5-methyl-N-(2,2,2-trifluoroethyl)benzenamine 
• 1357101-83-7 N₂-(4-tert-butoxycarbonyl-3,5-dimethyl)phenyl-5-methyl-N₄-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine 
• 1357101-76-8 N₂-(3,5-dimethyl-4-methoxymethyl)phenyl-5-methyl-N₄-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine 
• 1357101-75-7 N₂-(3,5-dimethyl-4-hydroxymethyl)phenyl-5-methyl-N₄-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine 
• 1357101-73-5 N₂-(4-carboxy-3,5-dimethyl)phenyl-5-methyl-N₄-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine 
• 306296-73-1 tert-butyl 4-amino-2,6-dimethylbenzoate 
• 306297-12-1 N₁-[4-(tert-butoxy)carbonyl-3,5-dimethylphenyl]-2,2,2-trifluoroacetamide 
• 306297-11-0 N-(4-bromo-3,5-dimethylphenyl)-2,2,2-trifluoro-acetamide 

Relevant articles and documents

Aminoazanium of DABCO: An Amination Reagent for Alkyl and Aryl Pinacol Boronates

The aminoazanium of DABCO (H2N-DABCO) has been developed as a general and practical amination reagent for the direct amination of alkyl and aryl pinacol boronates. This compound is stable and practical for use as a reagent. Various primary, secondary. and tertiary alkyl?Bpin and aryl?Bpin substrates were aminated to give the corresponding amine derivatives. The amination is stereospecific. The anti-Markovnikov hydroamination of olefins was easily achieved by catalytic hydroboration with HBpin and in subsequent situ amination using H2N-DABCO. Moreover, the combination of 1,2-diboration of olefins, using B2pin2, with this amination process achieved the unprecedented 1,2-diamination of olefins. The amination protocol was also successfully extended to aryl pinacol boronates.

Catalytic reduction of amides to amines by electrophilic phosphonium cations via FLP hydrosilylation

A catalytic methodology for the conversion of amides to amines is reported. Of the 25 examples described, 14 examples involve the reduction of N-trifluoroacetamides to the corresponding trifluoroethylamines. These reductions are achieved by catalytic hydrosilylation of the amide mediated by an electrophilic phosphonium cation (EPC) catalyst.

PIPERAZINE DERIVATIVES USEFUL AS CCR5 ANTAGONISTS

The use is described of CCR5 antagonists of formula (I) or a pharmaceutically acceptable salt thereof, wherein: R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R 1 is hydrogen or alkyl; R 2 is substituted phenyl, substituted heteroary