148256-82-0

Basic information

• Product Name: 4-Chloro-2-(methylthio)pyrimidine-5-carboxaldehyde
• Synonyms: 4-Chloro-2-(methylthio)pyrimidine-5-carboxaldehyde;4-chloro-2-(Methylthio)pyriMidine-5-carbaldehyde;5-PyriMidinecarboxaldehyde, 4-chloro-2-(Methylthio)-;4-chloro-2-(Methylsulfanyl)pyriMidine-5- carbaldehyde
• CAS NO: 148256-82-0
• Molecular Formula: C₆H₅ClN₂OS
• Molecular Weight: 189
• EINECS: -0
• Mol File: 148256-82-0.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 315℃
• Flash Point: 144℃
• Appearance: /
• Density: 1.44
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: -2.16±0.29(Predicted)
• CAS DataBase Reference: 4-Chloro-2-(methylthio)pyrimidine-5-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-2-(methylthio)pyrimidine-5-carboxaldehyde(148256-82-0)
• EPA Substance Registry System: 4-Chloro-2-(methylthio)pyrimidine-5-carboxaldehyde(148256-82-0)

Safety Data

• Hazardous Substances Data: 148256-82-0(Hazardous Substances Data)

Usage

General Description

4-Chloro-2-(methylthio)pyrimidine-5-carboxaldehyde is a chemical compound with the molecular formula C6H5ClN2OS. It is a pyrimidine derivative with a chlorine atom located at the fourth position and a methylthio group attached to the second position of the pyrimidine ring. The compound also features a carboxaldehyde group at the fifth position. It is commonly used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. The presence of the reactive aldehyde group makes it a key intermediate in the production of various valuable products, including anticancer and antiviral drugs. Additionally, it is utilized as a building block in the preparation of diverse heterocyclic compounds and has proven to be a versatile and important reagent in organic chemistry.

Upstream product

• 49844-90-8 4-Chloro-2-methylthiopyrimidine 
• 74840-34-9 4-chloro-2-(methylsulfanyl)pyrimidine-5-carboxylic acid 
• 5909-24-0 4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester 
• 1044145-59-6 [4-chloro-2-(methylsulfanyl)pyrimidin-5-yl]methanol 

Downstream Products

• 55084-74-7 6-methylsulfanyl-1⁽²⁾H-pyrazolo[3,4-d]pyrimidine 
• 1192309-52-6 1-{4-Chloro-3-[2-(2-dimethylamino-ethylamino)-8-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]-phenyl}-3-(3-chloro-4-methoxy-phenyl)-urea 
• 1192310-22-7 6-(2-chloro-5-nitrophenyl)-8-methoxy-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one 
• 1192310-23-8 6-(2-chloro-5-nitrophenyl)-2-(2-(dimethylamino)ethylamino)-8-methoxypyrido[2,3-d]pyrimidin-7(8H)-one 
• 1192310-18-1 6-(5-amino-2-chlorophenyl)-2-(2-(dimethylamino)ethylamino)-8-methoxypyrido[2,3-d]pyrimidin-7(8H)-one 
• 1192310-28-3 6-(2-chloro-4-nitrophenyl)-8-methoxy-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one 
• 1192310-29-4 6-(2-chloro-4-nitrophenyl)-2-(2-(dimethylamino)ethylamino)-8-methoxypyrido[2,3-d]pyrimidin-7(8H)-one 
• 1192310-24-9 6-(4-amino-2-chlorophenyl)-2-(2-(dimethylamino)ethylamino)-8-methoxypyrido[2,3-d]pyrimidin-7(8H)-one 
• 2260886-64-2 N-((1S,4S)-4-(3-(2-chlorophenyl)-7-((3-methyl-4-(4-methylpiperazin-1-yl)phenyl)amino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)cyclohexyl)propionamide 

Relevant articles and documents

Synthetic route of generic FGFR covalent inhibitor PRN1371

The invention relates to a synthetic route of a generic FGFR covalent inhibitor PRN1371, and belongs to the field of medicinal chemistry. The synthetic route steps of the PRN1371 comprise 11 steps, purification of a product can be achieved through simple operation of various intermediates in the aftertreatment process, the problems that the product is difficult to separate, the purification operation yield is low and the like are solved, and industrial production is facilitated. The invention aims to provide a synthetic route of the FGFR irreversible covalent inhibitor PRN1371, and the methodhas the advantages of few synthesis steps, simple operation, high yield, reduction of the production cost, and provision of a new synthesis idea for the industrial production of PRN1371.

BENZAMIDES OF PYRAZOLYL-AMINO-PYRIMIDINYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF

Provided is a novel class of orally and/or topically available, selective and potent JAK inhibitors as safe and effective therapeutics against various diseases and disorders. More particularly, provided are pharmaceutical composition of these compounds and methods of their preparation and use thereof.

Synthetic method of cyclopentyl pyrimido pyrroles compound

The invention discloses a synthetic method of a cyclopentyl pyrimido pyrroles compound, which belongs to the field of organic chemical synthesis. Through steps of reduction, oxidation, aldol condensation, aminolysis and nucleophilic substitution, the cyclopentyl pyrimido pyrroles compound is synthesized. The raw materials have the advantages of low cost and easy acquisition, a related intermediate is easily separated and purified, operation is simple, the method is friendly to environment, the purity of the product is high, and the product has good industrial prospect. The prepared cyclopentyl pyrimido pyrroles compound, especially 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazine-1-yl)pyridine-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-methanamide has inhibition effect on cyclin-dependent kinase CDK4/6, and has good clinical treatment effect on melanoma and breast cancer.