1483-27-8

Basic information

• Product Name: 2,5-DIMETHOXYTHIOPHENOL
• Synonyms: 2,5-DIMETHOXYBENZENETHIOL;2,5-DIMETHOXYTHIOPHENOL;2,5-DIMETHOXYTHIOPHENE;2C5-DIMETHOXYTHIOPHENOL;2,5-dimethoxybenzene-1-thiol;2,5-DIMETHOXYTHIOPHE;2,5-Dimethoxybenzenethiol, 2,5-Dimethoxyphenyl mercaptan;DiMethoxythiophenol
• CAS NO: 1483-27-8
• Molecular Formula: C₈H₁₀O₂S
• Molecular Weight: 170.23
• EINECS: -0
• Product Categories: Phenol&Thiophenol&Mercaptan;Phenoles and thiophenoles;Aromatics;Intermediates;Sulfur & Selenium Compounds
• Mol File: 1483-27-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 248.3-252.0 °C (decomp)
• Boiling Point: 88-90 °C0.5 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.134 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00707mmHg at 25°C
• Refractive Index: n20/D 1.5860(lit.)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Chloroform, Methanol
• PKA: 6.37±0.48(Predicted)
• Sensitive: Stench
• BRN: 1867842
• CAS DataBase Reference: 2,5-DIMETHOXYTHIOPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DIMETHOXYTHIOPHENOL(1483-27-8)
• EPA Substance Registry System: 2,5-DIMETHOXYTHIOPHENOL(1483-27-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: 2810
• WGK Germany: 3
• HazardClass: 9
• PackingGroup: III
• Hazardous Substances Data: 1483-27-8(Hazardous Substances Data)

Usage

Description

2,5-Dimethoxythiophenol is a thiophenol derivative characterized by its clear colorless to pale yellow oily appearance. It is known for its potential applications in the pharmaceutical industry, particularly in the development of antitumor agents and dihydrofolate reductase inhibitors.

Uses

Used in Pharmaceutical Industry:
2,5-Dimethoxythiophenol is used as a key intermediate compound for the synthesis of dihydrofolate reductase inhibitors, which are essential in the development of potential antitumor agents. Its unique chemical structure allows it to play a crucial role in the creation of these therapeutic agents, targeting cancer cell growth and proliferation.
Additionally, due to its s-alkylation properties, 2,5-Dimethoxythiophenol can be further modified and utilized in various chemical reactions to produce a range of compounds with potential applications in different industries.

InChI:InChI=1/C8H10O2S/c1-9-6-3-4-7(10-2)8(11)5-6/h3-5,11H,1-2H3

Upstream product

• 1483-28-9 2,5-dimethoxybenzene-1-sulfonyl chloride 
• 150-78-7 1,4-dimethoxybezene 
• 140-89-6 potassium ethyl xanthogenate 
• 25245-34-5 1-bromo-2,5-dimethoxybenzene 
• 102-56-7 2,5-dimethoxyaniline 

Downstream Products

• 1483-14-3 1,4-dimethoxy-2-(methylsulfonyl)benzene 
• 24920-54-5 (2,5-Dimethoxy-phenylsulfanylmethyl)-diphenyl-amine 
• 24920-52-3 (2,5-Dimethoxy-phenylsulfanylmethyl)-dimethyl-amine 
• 24920-50-1 2-(2-Chloro-ethylsulfanyl)-1,4-dimethoxy-benzene 
• 24920-51-2 C₁₈H₂₂O₄S₂ 
• 24920-53-4 (2,5-Dimethoxy-phenylsulfanylmethyl)-diethyl-amine 
• 648956-69-8 1,4-Dimethoxy-2-[(2-methylprop-2-enyl)thio]benzol 
• 849919-63-7 1,4-dimethoxy-2-(2-phenethyl)thiobenzene 
• 521308-46-3 8-(2,5-dimethoxy-phenylsulfanyl)adenine 
• 875449-87-9 3',5'-O-diacetyl-5-(2,5-dimethoxy-phenylsulfanylmethyl)-2'-deoxyuridine 
• 1097193-03-7 (difluoromethyl)(2,5-dimethoxyphenyl)sulfane 
• 190328-69-9 methyl 4,7-dimethoxybenzo[b]thiophene-2-carboxylate 
• 1649501-86-9 methyl (Z)-2-(2,5-dimethoxyphenylthio)-3-(dimethylamino)acrylate 
• 1649501-99-4 methyl 2-(2,5-dimethoxyphenylthio)acetate 

Relevant articles and documents

Synthesis of deuterium labeled phenethylamine derivatives

The synthesis of a series of five deuterium labeled phenethylamine derivatives, 4-bromo-2,5-[2H6]-dimethoxyphenethylamine (2C-B), 4-chloro-2,5-[2H6]-dimethoxyphenethylamine (2C-C), 2,5-[2H6]-dimethoxy-4-iodophenethylamine (2C-I), 2,5-[2H6]-dimethoxy-4-ethylthiophenethylamine (2C-T-2) and 2,5-[2H6]-dimethoxy-4-n-propylthiophenethylamine (2C-T-7) from 1,4-[2H6]-dimethoxybenzene is described. The isotopically labeled compounds are used as internal standards in gas chromatography-mass spectrometry (GC-MS) assays. Copyright

S-oxidation products of alkylthioamphetamines

The preparation of the sulfoxides and the sulfones of two centrally active alkylthioamphetamine salts, (±)-1-(4-methylthiophenyl)-2-aminopropane hydrochloride (2) (MTA · HCl) and (±)-1-(2,5-dimethoxy-4-ethylthiophenyl)-2-aminopropane hydrochloride (7) (AL

Monomethylthio analogues of 1-(2,4,5-trimethoxyphenyl)-2-aminopropane

Regiospecific syntheses of the three monomethylthio analogues of 1-(2,4,5- trimethoxyphenyl)-2-aminopropane are described. The three isomeric amines were evaluated for potential psychotomimetic potency using the rabbit hyperthermia assay. Enantiomeric com