148322-13-8

Basic information

• Product Name: 5-iodo-2-methyl-3-(phenylthio)indole
• Synonyms: 5-iodo-2-methyl-3-(phenylthio)indole
• CAS NO: 148322-13-8
• Molecular Weight: 365.237
• Mol File: 148322-13-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-iodo-2-methyl-3-(phenylthio)indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-iodo-2-methyl-3-(phenylthio)indole(148322-13-8)
• EPA Substance Registry System: 5-iodo-2-methyl-3-(phenylthio)indole(148322-13-8)

Safety Data

• Hazardous Substances Data: 148322-13-8(Hazardous Substances Data)

Upstream product

• 5042-53-5 1-(phenylsulfanyl)acetone 
• 540-37-4 p-aminoiodobenzene 

Downstream Products

• 236747-82-3 methyl 2-{4-[2-methyl-3-(phenylthio)-1H-5-indolyl]phenyl}propanoate 

Relevant articles and documents

Nonreductive Desulfenylation of 3-Indolyl Sulfides. Improved Syntheses of 2-Substituted Indoles and 2-Indolyl Sulfides

Desulfenylation of 3-indolyl sulfides to the corresponding 3-unsubstituted indoles is usually carried out under reductive conditions, thus accommodating only substituents which are resistant to reduction.We have developed a nonreductive procedure for removal of a sulfide at the 3-position of indoles, using trifluoroacetic acid in the presence of a thiol as trapping agent, which is compatible with a large array of functionalities on the indole ring.In addition, the desulfenylation occurs selectively at the 3-position of the indole, and sulfide groups at other positions of the molecule remain untouched.Thus, indole 2,3-bis-sulfides are selectively desulfenylated at the 3-position, affording 3-unsubstituted 2-indolyl sulfides.This methodology broadens the use of sulfide as a protecting group for the 3-position of indoles.