148324-45-2

Basic information

• Product Name: 2-(4'-benzyloxyphenyl)-1-(3-hydroxy-2-ethoxycarbonylphenyl)ethene
• Synonyms: 2-(4'-benzyloxyphenyl)-1-(3-hydroxy-2-ethoxycarbonylphenyl)ethene
• CAS NO: 148324-45-2
• Molecular Weight: 374.436
• Mol File: 148324-45-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4'-benzyloxyphenyl)-1-(3-hydroxy-2-ethoxycarbonylphenyl)ethene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4'-benzyloxyphenyl)-1-(3-hydroxy-2-ethoxycarbonylphenyl)ethene(148324-45-2)
• EPA Substance Registry System: 2-(4'-benzyloxyphenyl)-1-(3-hydroxy-2-ethoxycarbonylphenyl)ethene(148324-45-2)

Safety Data

• Hazardous Substances Data: 148324-45-2(Hazardous Substances Data)

Upstream product

• 4397-53-9 p-benzyloxybenzaldehyde 
• 118842-88-9 (3-acetyloxy-2-ethoxycarbonylbenzyl)-triphenylphosphonium bromide 

Downstream Products

• 637774-32-4 3-(4'-benzyloxyphenyl)-8-hydroxy-3,4-dihydro-2-benzopyran-1-one 
• 480-47-7 hydrangenol 
• 148324-47-4 2-(4'-benzyloxyphenyl)-1-(3-hydroxy-2-ethoxycarbonylphenyl)ethene 

Relevant articles and documents

Efficient syntheses of (+/-)-hydrangenol, (+/-)-phyllodulcin and (+/-)-macrophyllol

In this paper we report on a efficient and flexible synthetic route towards the total syntheses of the dihydrocoumarine derivatives hydrangenol (1), phyllodulcin (1a) and macrophyllol (6b). The syntheses started with a readily available phosphonium salt 2 and suitable modified benzaldehydes 3/3a/3b resulting in 46 to 61 percent overall yields in three to four-steps sequences. The racemic products could be separated by chiral HPLC. The evidence of the (R)-enantiomer for sweetness could be demonstrated for 1a.