1484-05-5Relevant articles and documents
Anionic Cycloaddition Reactions Of Indole-2,3-dienolate With Dienophiles: A Facile Regiospecific Route To Substituted Carbazoles
Rao, Mandava V. Basaveswara,Satyanarayana, Janagani,Ila, Hiriyakkanavar,Junjappa, Hiriyakkanavar
, p. 3385 - 3388 (1995)
Indole 2,3-dienolate derived by deprotonation of 1,2-dimethylindole-3-carboxaldehyde is shown to be useful 1,4-dipole synthon (anionic indolo-2,3-quinodimethane) which undergoes facile cycloaddition with wide range of dienophiles affording substituted car
A Green Synthesis of 2-Amino-4-(9H-carbazole-3-yl)thiophene-3-carbonitriles by a Step-wise and One-pot Three-component Gewald Reaction
Avula, Vijay Kumar Reddy,Vallela, Swetha,Anireddy, Jaya Shree,Chamarthi, Naga Raju
, p. 2471 - 2482 (2017/07/25)
An eco-friendly method has been developed for the synthesis of 2-amino-4-(9H-carbazole-3-yl)thiophene-3-carbonitriles from preliminary carbazole (1) through an intermediate of 2-(1-(9H-carbazole-3-yl)ethylidene)malononitriles using the Knoevenagel condensation followed by the Gewald reaction. On the other hand, the target compounds could also be prepared in a one-pot three-component manner by treating equimolar quantities of 1-(9H-carbazole-3-yl)ethanone (3), malononitrile, and elemental sulfur. The merits of this preparation are mild reaction conditions. The Gewald reaction is executed with inorganic base NaHCO3 (H2O) in tetrahydrofuran, easy work-up procedure with good yields.
Design, synthesis, and structure-activity correlations of novel dibenzo[b,d furan, dibenzo[b,d]thiophene, and N-methylcarbazole clubbed 1,2,3-triazoles as potent inhibitors of mycobacterium tuberculosis
Patpi, Santhosh Reddy,Pulipati, Lokesh,Yogeeswari, Perumal,Sriram, Dharmarajan,Jain, Nishant,Sridhar, Balasubramanian,Murthy, Ramalinga,Anjana Devi,Kalivendi, Shasi Vardhan,Kantevari, Srinivas
experimental part, p. 3911 - 3922 (2012/07/14)
A molecular hybridization approach is an emerging structural modification tool to design new molecules with improved pharmacophoric properties. In this study, 1,2,3-triazole-based Mycobacterium tuberculosis inhibitors and synthetic and natural product-bas