148408-72-4

Basic information

• Product Name: (R)-(+)-1-Methyl-α-phenyl-1H-pyrazole-5-methanol
• Synonyms: (R)-(+)-1-Methyl-α-phenyl-1H-pyrazole-5-methanol
• CAS NO: 148408-72-4
• Molecular Weight: 188.229
• Mol File: 148408-72-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (R)-(+)-1-Methyl-α-phenyl-1H-pyrazole-5-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-1-Methyl-α-phenyl-1H-pyrazole-5-methanol(148408-72-4)
• EPA Substance Registry System: (R)-(+)-1-Methyl-α-phenyl-1H-pyrazole-5-methanol(148408-72-4)

Safety Data

• Hazardous Substances Data: 148408-72-4(Hazardous Substances Data)

Upstream product

• 3262-89-3 triphenylboroxine 
• 27258-33-9 1-methyl-1H-pyrazole-5-carbaldehyde 
• 61496-24-0 (1-methyl-1H-pyrazol-5-yl)(phenyl)methanone 
• 13276-04-5 triphenylborane * ammonia 
• 524-95-8 2-Aminoethoxydiphenylborane 

Downstream Products

• 148981-62-8 (R)-(+)-Cizolirtine 

Relevant articles and documents

Enantioselective synthesis of (R)- and (S)-cizolirtine; application of oxazaborolidine-catalyzed asymmetric borane reduction to azolyl phenyl ketones

An efficient enantioselective synthesis of (R)- and (S)cizolirtine 1 is described. The key step of the procedure is the CBS-oxazaborolidine asymmetric reduction of phenyl pyrazolyl ketone 2. Related enantioselective reductions of several azolyl phenyl ketones are also reported.

Practical implications of boron-to-zinc transmetalation for the catalytic asymmetric arylation of aldehydes

(Chemical Equation Presented) Faster than believed: Transmetalation from aryl boronic acids and triaryl boroxines to diethylzinc takes place within minutes following a two-step, low-energy pathway (see picture), according to density functional calculations and reaction microcalorimetry measurements. The experimental conditions for a practical, atom-economical, and highly enantioselective catalytic arylation of a variety of aldehydes have been developed from these data.

Process for obtaining enantiomers of cizolirtine

A process is described for the preparation of a precursor alcohol of Cizolirtine, (±)-2-[phenyl(1-methyl-1H-pyrazol-5-yl)methoxy]-N,N-dimethylethanamine and its enantiomers, it comprises the asymmetric reduction of a prochiral ketone in the presence of a