148493-16-7

Basic information

• Product Name: Pentanoic acid, 2-methyl-4-oxo-, (2S)- (9CI)
• Synonyms: Pentanoic acid, 2-methyl-4-oxo-, (2S)- (9CI)
• CAS NO: 148493-16-7
• Molecular Formula: C₆H₁₀O₃
• Molecular Weight: 130.1418
• Product Categories: ACETYLGROUP
• Mol File: 148493-16-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pentanoic acid, 2-methyl-4-oxo-, (2S)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pentanoic acid, 2-methyl-4-oxo-, (2S)- (9CI)(148493-16-7)
• EPA Substance Registry System: Pentanoic acid, 2-methyl-4-oxo-, (2S)- (9CI)(148493-16-7)

Safety Data

• Hazardous Substances Data: 148493-16-7(Hazardous Substances Data)

Upstream product

• 32811-25-9 methyl 2-methyl-4-oxo-pentanoate 
• 16507-04-3 methyl 2-methyl-4-nitropentanoate 
• 440084-24-2 (2S)-(–)-methyl 2-methyl-4-oxopentanoate 
• 915768-07-9 (S)-2-Acetyl-3-methyl-succinic acid 1-tert-butyl ester 4-methyl ester 

Downstream Products

• 440084-24-2 (2S)-(–)-methyl 2-methyl-4-oxopentanoate 

Relevant articles and documents

A new chiral alkylation methodology for the synthesis of 2-alkyl-4-ketoacids in high optical purity using 2-triflyloxy esters

Optical active 2-triflyloxy esters are excellent alkylating agents for β-ketoester enolates. Decarboxylation of the alkylation products gives 2-substituted-4-ketoacid derivatives in high optical purities.

The Stereoselective Synthesis of 2-Alkyl γ-Keto Acid and Heterocyclic Ketomethylene Peptide Isostere Core Units Using Chiral Alkylation by 2-Triflyloxy Esters

A simple and general protocol for the enentioselective preparation of γ-keto acids and heterocyclic γ-keto acids which have an alkyl group at C-2 is reported.The alkyl group is introduced by chiral alkylation using a scalemic 2-triflyoxy ester.The alkylation takes place with inversion of configuration and is compatible with a variety of alkyl groups.This methodology is thus wellsuited for the preparation of a wide variety of ketomethylene peptide isosteres.