14850-87-4

Basic information

• Product Name: (E)-N′-(4-methoxybenzylidene)benzohydrazide
• Synonyms: (E)-N′-(4-methoxybenzylidene)benzohydrazide
• CAS NO: 14850-87-4
• Molecular Weight: 254.288
• Mol File: 14850-87-4.mol
• Article Data: 40

Chemical Properties

• CAS DataBase Reference: (E)-N′-(4-methoxybenzylidene)benzohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-N′-(4-methoxybenzylidene)benzohydrazide(14850-87-4)
• EPA Substance Registry System: (E)-N′-(4-methoxybenzylidene)benzohydrazide(14850-87-4)

Safety Data

• Hazardous Substances Data: 14850-87-4(Hazardous Substances Data)

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 613-94-5 benzoic acid hydrazide 
• 93-58-3 benzoic acid methyl ester 
• 65-85-0 benzoic acid 
• 93-89-0 benzoic acid ethyl ester 
• 91099-00-2 2'-(4-methoxybenzyl)benzohydrazide 

Downstream Products

• 842-79-5 2-(4-methoxy-phenyl)-5-phenyl-[1,3,4]oxadiazole 
• 2299-73-2 N,N-bis(4-methoxybenzylidene)hydrazine 
• 98-88-4 benzoyl chloride 
• 69341-73-7 1-chloro-4-(4-methoxyphenyl)-1-phenyl-2,3-diazabutadiene 
• 108618-31-1 7-methoxy-1-phenyl-phthalazine 
• 554447-15-3 (S)-benzoic acid N'-[1-(4-methoxyphenyl)but-3-enyl]hydrazide 
• 77420-69-0 N-[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-N'-[1-phenyl-1-thiocyanato-meth-(Z)-ylidene]-hydrazine 
• 1236179-35-3 (3-isopropyl-4-phenyl-4,5-dihydro-1H-pyrazol-1-yl)(phenyl)methanone 
• 1242282-89-8 diethyl 2-[(E)-1-benzoyl-2-(4-methoxybenzylidene)hydrazinyl]fumarate 
• 1366284-26-5 N-(2,2-difluoro-1-(4-methoxyphenyl)-3-oxo-3-phenylpropyl)benzohydrazide 

Relevant articles and documents

Synthesis and Fluorescence Properties of Eu3+, Tb3+ Complexes with Schiff Base Derivatives

Novel Schiff base ligands derived from N′-benzylidene-benzohydrazide (substituted by-H,-CH3,-OCH3,-Cl) and 2-chloro-N-phenylacetamide were synthesized. The solid complexes of rare earth (Eu, Tb) nitrate with these Schiff base ligands

p-methoxybenzaldehyde benzoylhydrazone monohydrate

The crystal structure of the title compound, C15H14N2O2·H2O, is in the keto tautomeric form and the configuration at the azomethine C double bond N double bond is E. The molecule is non-planar, with a dihedral angle of 27.3 (1)° between the aromatic rings. The crystal structure is stabilized by extensive hydrogen bonding involving the water molecule and hydrazone moiety.

Modulation of estrogen-related receptors subtype selectivity: Conversion of an ERRβ/γ selective agonist to ERRα/β/γ pan agonists

Estrogen Related Receptors (ERRs) are key regulators of energy homeostasis and play important role in the etiology of metabolic disorders, skeletal muscle related disorders, and neurodegenerative diseases. Among the three ERR isoforms, ERRα emerged as a potential drug target for metabolic and neurodegenerative diseases. Although ERRβ/γ selective agonist chemical tools have been identified, there are no chemical tools that effectively target ERRα agonism. We successfully engineered high affinity ERRα agonism into a chemical scaffold that displays selective ERRβ/γ agonist activity (GSK4716), providing novel ERRα/β/γ pan agonists that can be used as tools to probe the physiological roles of these nuclear receptors. We identified the structural requirements to enhance selectivity toward ERRα. Molecular modeling shows that our novel modulators have favorable binding modes in the LBP of ERRα and can induce conformational changes where Phe328 that originally occupies the pocket is dislocated to accommodate the ligands in a rather small cavity. The best agonists up-regulated the expression of target genes PGC-1α and PGC-1β, which are necessary to achieve maximal mitochondrial biogenesis. Moreover, they increased the mRNA levels of PDK4, which play an important role in energy homeostasis.

Sodium hypochlorite-mediated synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from hydrazides and aldehydes

[Figure not available: see fulltext.] A simple and convenient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles has been developed. Structurally divergent symmetrical and unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles can be obtained in moderate to high yields via NaOCl-mediated oxidative cyclization of N-acylhydrazones, generated in situ from aliphatic and aromatic hydrazides and aldehydes.