148528-89-6Relevant articles and documents
KV3 MODULATORS
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Page/Page column 51; 63-64, (2021/08/14)
A compound of formula (I) and related aspects.
CYCLOBUTANE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED POTASSIUM CHANNELS
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Page/Page column 112, (2018/02/28)
The present invention provides compounds of the formula (I) and their use as Kv3 modulators.
Structure-based design of agents targeting the bacterial ribosome
Bower, Justin,Drysdale, Martin,Hebdon, Richard,Jordan, Allan,Lentzen, Georg,Matassova, Natalia,Murchie, Alastair,Powles, Jenifer,Roughley, Stephen
, p. 2455 - 2458 (2007/10/03)
Rational structure-based drug design has been applied to the antibiotic thiostrepton, in an attempt to overcome some of its' limitations. The identification of a proposed binding fragment allowed construction of a number of key fragments, which were derivatised to generate a library of potential antibiotics. These were then evaluated to determine their ability to bind to the L11 binding domain of the prokaryotic ribosome and inhibit bacterial protein translation.