148596-90-1 Usage
Description
21-Hydroxy DeschloroMoMetasone Furoate (IMpurity) is an impurity found in Mometasone Furoate (M490000), which is a topical corticosteroid. 21-Hydroxy DeschloroMoMetasone Furoate (IMpurity) is characterized by its white to off-white solid appearance and is known for its anti-inflammatory properties.
Uses
Used in Pharmaceutical Industry:
21-Hydroxy DeschloroMoMetasone Furoate (IMpurity) is used as an impurity in the production of Mometasone Furoate, a topical corticosteroid. It plays a role in the development and formulation of anti-inflammatory medications, specifically for topical use.
Used in Research and Development:
In the field of pharmaceutical research and development, 21-Hydroxy DeschloroMoMetasone Furoate (IMpurity) is utilized for studying the properties, effects, and potential improvements of Mometasone Furoate. This helps in understanding the compound's behavior and its impact on the overall efficacy and safety of the final product.
Used in Quality Control:
21-Hydroxy DeschloroMoMetasone Furoate (IMpurity) is also used in the quality control process of Mometasone Furoate manufacturing. By monitoring the presence and concentration of this impurity, manufacturers can ensure the quality, purity, and consistency of the final product, which is crucial for its safety and effectiveness in treating inflammation.
Check Digit Verification of cas no
The CAS Registry Mumber 148596-90-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,8,5,9 and 6 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 148596-90:
(8*1)+(7*4)+(6*8)+(5*5)+(4*9)+(3*6)+(2*9)+(1*0)=181
181 % 10 = 1
So 148596-90-1 is a valid CAS Registry Number.
148596-90-1Relevant articles and documents
Improvements in corticosteroid 21-acetoxy-17α-hydroxy-16α-methyl-pregna-1,4,9(11)-triene-3,20-dione synthesis and its use as common intermediate in the synthesis of some impurities related to dexamethasone and mometasone
Das, Saibal Kumar,Dubey, Manoj Kumar,Buchhikonda, Ravinder
, p. 47 - 55 (2019)
There are quite substantial number of impurities related to dexamethasone or mometasone which cannot be made from respective Active Pharmaceutical Ingredients but from common intermediate 21-acetoxy-17α-hydroxy-16α-methyl-pregna-1,4,9(11)-triene-3,20-dione (12). As such, a robust and economical synthesis of this key intermediate is important for delivering a resilient and economically viable supply chain for these impurities. Therefore, it is critical to have a robust and economically viable process to synthesize the intermediate 12 in good yield and quality. We report here an improved synthesis of 12 and eight impurities related to dexamethasone and mometasone from this common intermediate.
