1486-63-1

Basic information

• Product Name: 4H-1-Benzopyran-4-one, 2-[3,4-bis(phenylmethoxy)phenyl]-5-hydroxy-3,7-bis(phenylmethoxy)-
• CAS NO: 1486-63-1
• Molecular Formula: C43H34O7
• Molecular Weight: 662.739
• Mol File: 1486-63-1.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: 4H-1-Benzopyran-4-one, 2-[3,4-bis(phenylmethoxy)phenyl]-5-hydroxy-3,7-bis(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1-Benzopyran-4-one, 2-[3,4-bis(phenylmethoxy)phenyl]-5-hydroxy-3,7-bis(phenylmethoxy)-(1486-63-1)
• EPA Substance Registry System: 4H-1-Benzopyran-4-one, 2-[3,4-bis(phenylmethoxy)phenyl]-5-hydroxy-3,7-bis(phenylmethoxy)-(1486-63-1)

Safety Data

• Hazardous Substances Data: 1486-63-1(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 117-39-5 quercetol 
• 100-44-7 benzyl chloride 
• 1064-06-8 3,5,7-triacetoxy-2-(3,4-diacetoxy-phenyl)-chromen-4-one 
• 13157-90-9 2-[3,4-bis(phenylmethoxy)phenyl]-3,5,7-tris(phenylmethoxy)chromen-4-one 
• 13459-13-7 7,4’-di-O-benzylquercetin 

Downstream Products

• 1592-68-3 2-(3,4-bis(benzyloxy)phenyl)-3,7-(dibenzyloxy)-5-methoxy-4H-chromen-4-one 
• 1610737-58-0 3,7-bis(benzyloxy)-2-(3,4-bis(benzyloxy)phenyl)-5-((4-fluorobenzyl)oxy)-4H-chromen-4-one 
• 1610737-76-2 2-(3,4-dihydroxyphenyl)-5-((4-fluorobenzyl)oxy)-3,7-dihydroxy-4H-chromen-4-one 
• 529-51-1 5-O-methylquercetin 
• 1355333-76-4 3,7-di(benzyloxy)-2-(3,4-dibenzyloxyphenyl)-5-allyloxy-4-oxo-4H-chromene 
• 1355333-54-8 3,7-(dihydroxy)-2-(3,4-dihydroxyphenyl)-5-propyloxy-4-oxo-4H-chromene 
• 1313191-76-2 3,7-bisbenzyloxy-2-(3,4-bisbenzyloxyphenyl)-5-(2,3,4,6-tetra-O-acetyl)-β-D-glucopyranosyloxy-4H-chromen-4-one 
• 34199-21-8 quercetin 5‐O‐β‐D‐glucopyranoside 
• 40554-90-3 3,7-bisbenzyloxy-2-(3,4-bisbenzyloxyphenyl)-5-β-D-glucopyranosyloxy-4H-chromen-4-one 
• 367522-85-8 quercetin 5-O-β-D-glucuronide 
• 1144104-67-5 Methyl 2-((3,7-Bis(benzyloxy)-2-(3,4-bis(benzyloxy)-phenyl)-4-oxo-4H-chromen-5-yl)oxy)acetate 
• 357194-16-2 3,7-bis(benzyloxy)-2-[3,4-bis(benzyloxy)phenyl]-5-(β-D-galactopyranosyloxy)-4H-1-benzopyran-4-one 
• 357194-05-9 3,7-dihydroxy-2-(3,4-dihydroxyphenyl)-5-(β-D-galactopyranosyloxy)-4H-1-benzopyran-4-one 

Relevant articles and documents

Clarification of the role of quercetin hydroxyl groups in superoxide generation and cell apoptosis by chemical modification

Accumulated data have suggested that the hydroxyl groups of flavonoids are important for their bioactive function. To directly demonstrate the role of hydroxyl groups, we synthesized a derivative of quercetin, 3,7,3',4'-0- tetrabenzylquercetin (4Bn-Q) tha

Quercetin derivative and preparation method thereof (by machine translation)

The invention discloses a quercetin derivative and a preparation method, and application thereof. The invention belongs to the field, and aims to solve the problems, such as poor water solubility, low bioavailability and the like in the prior art, provides a quercetin derivative, and the obtained quercetin derivative is far better than quercetin, has higher bioavailability, and can be used for treating cardiovascular and cerebrovascular diseases, resisting cancers and preventing cancer. Another object of the present invention is to provide a method, using quercetin, for protecting a hydroxyl, followed by substitution reaction and hydrogenation reaction to prepare a quercetin derivative, and a method for synthesizing the quercetin derivative. To the invention, the natural quercetin derivative, by substitution reaction at 5 - OH hydroxyl level, is beneficial to improving the water solubility and fat solubility, improving the bioavailability, and the method is simple in principle 37% - 57%, and high in product yield, 96% - 98%f =0000000.5. (by machine translation)

Synthesis and characterization of novel flavonoid derivatives via sequential phosphorylation of quercetin

Flavonoids are naturally-occurring polyphenolics that have been implicated in a wide range of biological activities. The major obstacles to flavonoid applications are the poor solubility in common solvents. Phosphorylation of flavonoids yields a new class of flavonoid derivatives which are very soluble in aqueous solutions and hence have the potential to be used in biological studies. We hereby report the sequential phosphorylation of Quercetin leading to the synthesis of Quercetin pentaphosphate (QPP), Apigenin triphosphate (ATRP), 5,4′-Quercetin Diphosphate (5,4′-QDP) and 4′-Quercetin monophosphate (4′-QP) with solubility of 848?mg/mL, 367?mg/mL, 315?μg/mL and 106?μg/mL respectively. The synthesis of 4′-QP, 5,4′-QDP, QPP and ATRP was successful with 85%, 60.5%, 56% and 99% yield respectively. These compounds have been characterized using 1H NMR, 13C NMR, 31P NMR.