148651-35-8 Usage
Description
2-Chlorophenylzinc iodide is an organozinc compound characterized by its reactivity in various chemical reactions, particularly in cross-coupling processes. It possesses a unique structure that allows it to form carbon-carbon bonds and is widely utilized in the synthesis of complex organic molecules.
Uses
Used in Pharmaceutical Industry:
2-Chlorophenylzinc iodide is used as a reactant for the Negishi cross-coupling reaction, which is crucial for constructing carbon-carbon bonds in the synthesis of various pharmaceutical compounds. This reaction is facilitated by nickel or palladium catalysts, enabling the formation of new molecular structures with potential therapeutic applications.
Used in Chemical Synthesis:
2-Chlorophenylzinc iodide is used as a reactant for the preparation of arylmethanes through a rhodium-catalyzed cross-coupling reaction with methyl halides. This application is significant in the synthesis of complex organic molecules, which can be further utilized in various chemical and pharmaceutical processes.
Used in Material Science:
In the field of material science, 2-chlorophenylzinc iodide is used as a reactant to produce (2-chlorobenzyl)trimethylsilane via a Rh-catalyzed cross-coupling reaction with (iodomethyl)trimethylsilane. 2-CHLOROPHENYLZINC IODIDE can be employed in the development of new materials with specific properties, such as improved stability or reactivity.
Used in Environmental Applications:
2-Chlorophenylzinc iodide is also used in the synthesis of dichlorobiphenyl through a palladium-catalyzed oxidative homocoupling reaction using N-chlorosuccinimide (NCS) or O2 as the oxidant. This process is relevant in the production of certain chemicals and materials that can be utilized in various environmental applications, such as waste management and pollution control.
Check Digit Verification of cas no
The CAS Registry Mumber 148651-35-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,8,6,5 and 1 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 148651-35:
(8*1)+(7*4)+(6*8)+(5*6)+(4*5)+(3*1)+(2*3)+(1*5)=148
148 % 10 = 8
So 148651-35-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H4Cl.HI.Zn/c7-6-4-2-1-3-5-6;;/h1-4H;1H;/q;;+1/p-1/rC6H4ClIZn/c7-5-3-1-2-4-6(5)9-8/h1-4H
148651-35-8Relevant articles and documents
Ultrasound-Promoted Synthesis of Arylzinc Compounds Using Zinc Powder and Their Application to Palladium(0)-Catalyzed Synthesis of Multifunctional Biaryls
Takagi, Kentaro
, p. 469 - 472 (1993)
Arylzinc compounds containing electron-withdrawing groups such as CO2CH3, CON(CH3)2, CN, Br, Cl, or CF3 at ortho position were prepared readily by the ultrasound-promoted reaction of aryl iodides with zinc powder, which were applied to palladium(0)-catalyzed cross-coupling with aryl halides to afford unsymmetrical and multifunctional biaryls in good yields.
