148651-41-6 Usage
Description
[1,1'-Biphenyl]-2-carboxylic acid, 4'-acetyl-, methyl ester is an organic compound characterized by its molecular formula C17H16O3. It is a methyl ester derivative of the 4'-acetyl-[1,1'-biphenyl]-2-carboxylic acid, known for its versatile functional groups and reactivity. [1,1'-Biphenyl]-2-carboxylic acid, 4'-acetyl-, methyl ester serves as a valuable building block in the synthesis of novel chemical compounds and pharmaceutical products, making it a significant contributor to organic synthesis and pharmaceutical research.
Uses
Used in Pharmaceutical Research:
[1,1'-Biphenyl]-2-carboxylic acid, 4'-acetyl-, methyl ester is used as a precursor in the pharmaceutical industry for the production of various medications and pharmaceutical compounds. Its unique structure and functional groups make it an essential component in the development of new drugs and therapies.
Used in Organic Synthesis:
In the field of organic synthesis, [1,1'-Biphenyl]-2-carboxylic acid, 4'-acetyl-, methyl ester is utilized as a key intermediate for creating a wide range of chemical compounds. Its reactivity and structural properties allow for the synthesis of complex molecules with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Used in Drug Development:
[1,1'-Biphenyl]-2-carboxylic acid, 4'-acetyl-, methyl ester is also employed in the development and manufacturing of pharmaceutical drugs. Its versatile nature allows for the creation of new drug candidates with improved efficacy, safety, and pharmacokinetic profiles. This contributes to the ongoing efforts in drug discovery and the advancement of medical treatments for various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 148651-41-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,8,6,5 and 1 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 148651-41:
(8*1)+(7*4)+(6*8)+(5*6)+(4*5)+(3*1)+(2*4)+(1*1)=146
146 % 10 = 6
So 148651-41-6 is a valid CAS Registry Number.
148651-41-6Relevant articles and documents
Silver-Catalyzed C(sp2)-H Functionalization/C-O Cyclization Reaction at Room Temperature
Dai, Jian-Jun,Xu, Wen-Tao,Wu, Ya-Dong,Zhang, Wen-Man,Gong, Ying,He, Xia-Ping,Zhang, Xin-Qing,Xu, Hua-Jian
, p. 911 - 919 (2015)
Silver-catalyzed C(sp2)-H functionalization/C-O cyclization has been developed. The scalable reaction proceeds at room temperature in an open flask. The present method exhibits good functional-group compatibility because of the mild reaction conditions. Using a AgNO3 catalyst and a (NH4)2S2O8 oxidant in CH2Cl2/H2O solvent, various lactones are obtained in good to excellent yields. A kinetic isotope effect (KIE) study indicates that the reaction may occur via a radical process.
A method of manufacturing a fluorene derivative (by machine translation)
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Paragraph 0028, (2020/02/26)
PROBLEM TO BE SOLVED: To provide an economically and industrially advantageous method of producing 9-fluorenone and its derivatives on an industrial scale.SOLUTION: An economically and industrially advantageous method of producing 9-fluorenone and its derivatives comprises carrying out an intramolecular cyclization reaction of a biaryl carboxylic acid and its derivative in the presence of a rhodium salt and/or a rhodium complex and an acid anhydride. The efficiency of production of the compounds is improved further by adding an alkali metal halide or 1,2-bis(diphenylphosphino)ethane in the intramolecular cyclization reaction.
Synthesis of fluorenones through rhodium-catalyzed intramolecular acylation of biarylcarboxylic acids
Fukuyama, Takahide,Maetani, Shinji,Miyagawa, Kazusa,Ryu, Ilhyong
supporting information, p. 3216 - 3219 (2014/07/08)
An efficient approach to the synthesis of fluorenones via the rhodium-catalyzed intramolecular acylation of biarylcarboxylic acids was developed. Using this procedure, fluorenones with various substituents can be synthesized in good to high yields. This work marks the first recorded use of catalytic intramolecular acylation to synthesize fluorenones.
