148869-69-6

Basic information

• Product Name: 1H-1,2,4-Triazol-1-amine, N-(4-nitrophenyl)-
• CAS NO: 148869-69-6
• Molecular Formula: C8H7N5O2
• Molecular Weight: 205.176
• Mol File: 148869-69-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-1,2,4-Triazol-1-amine, N-(4-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-1,2,4-Triazol-1-amine, N-(4-nitrophenyl)-(148869-69-6)
• EPA Substance Registry System: 1H-1,2,4-Triazol-1-amine, N-(4-nitrophenyl)-(148869-69-6)

Safety Data

• Hazardous Substances Data: 148869-69-6(Hazardous Substances Data)

Upstream product

• 24994-60-3 1-amino-1,2,4-triazole 
• 350-46-9 4-Fluoronitrobenzene 

Relevant articles and documents

Studies on aromatase inhibitors. II. Synthesis and biological evaluation of 1-amino-1H-1,2,4-triazole derivatives

1-N,N-Disubstituted amino-1H-1,2,4-triazole derivatives were prepared and evaluated for aromatase-inhibitory activity (in vitro) and for the inhibitory activity on pregnant mare serum gonadotropin (PMSG)-induced estrogen synthesis (in vivo). 1-N-para-Substituted benzylamino derivatives, having an electron-withdrawing group on the phenyl moiety, exhibited aromatase-inhibitory activity in vitro and in vivo. Among them, 1-[(4- nitrobenzyl)(4-nitrophenyl)amino]-1H-1,2,4-triazole (5b) was the most potent aromatase inhibitor. These 1-N-benzylamino derivatives also showed relatively strong inhibitory activity on aldosterone synthesis, indicating that the selectivity of these derivatives for aromatase inhibition was not sufficient in comparison with that of the 4-amino-4H-1,2,4-triazole derivatives.