148960-39-8

Basic information

• Product Name: 1H-Inden-1-amine,5-fluoro-2,3-dihydro-,(-)-(9CI)
• Synonyms: 1H-Inden-1-amine,5-fluoro-2,3-dihydro-,(-)-(9CI)
• CAS NO: 148960-39-8
• Molecular Formula: C₉H₁₀FN
• Molecular Weight: 151.18
• Product Categories: HALIDE;CYCLOPENTANE
• Mol File: 148960-39-8.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Inden-1-amine,5-fluoro-2,3-dihydro-,(-)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Inden-1-amine,5-fluoro-2,3-dihydro-,(-)-(9CI)(148960-39-8)
• EPA Substance Registry System: 1H-Inden-1-amine,5-fluoro-2,3-dihydro-,(-)-(9CI)(148960-39-8)

Safety Data

• Hazardous Substances Data: 148960-39-8(Hazardous Substances Data)

Usage

Structure

Bicyclic aromatic amine

Fluorinated derivative

Contains a fluorine atom

Chiral molecule

Has non-superimposable mirror image

Stereochemistry

(-)-(9CI) designation

Potential use

Pharmaceutical applications or as a building block for synthesis

Safety

Handle with care and follow proper safety protocols and regulations

Upstream product

• 700-84-5 5-fluoro-1-indanone 
• 7440-66-6 zinc 
• 148960-32-1 5-fluoro-1-indanone oxime 

Downstream Products

• 1114333-11-7 (R)-5-fluoro-2,3-dihydro-1H-inden-1-amine 

Relevant articles and documents

Deconstructive Oxygenation of Unstrained Cycloalkanamines

A deconstructive oxygenation of unstrained primary cycloalkanamines has been developed for the first time using an auto-oxidative aromatization promoted C(sp3)?C(sp3) bond cleavage strategy. This metal-free method involves the substitution reaction of cycloalkanamines with hydrazonyl chlorides and subsequent auto-oxidative annulation to in situ generate pre-aromatics, followed by N-radical-promoted ring-opening and further oxygenation by 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and m-cholorperoxybenzoic acid (mCPBA). Consequently, a series of 1,2,4-triazole-containing acyclic carbonyl compounds were efficiently produced. This protocol features a one-pot operation, mild reaction conditions, high regioselectivity and ring-opening efficiency, broad substrate scope, and is compatible with alkaloids, osamines, and peptides, as well as steroids.

METALLOENZYME INHIBITOR COMPOUNDS

Provided are compounds having HDAC6 modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by HDAC6.

POTENT SMALL MOLECULE INHIBITORS OF AUTOPHAGY, AND METHODS OF USE THEREOF

Certain aspects of the invention relate to small molecule autophagy inhibitors, and their use for treatment and prevention of cancers and acute pancreatitis. Medicinal chemistry studies led to small molecular autophagy inhibitors with improved potency and selectivity.