149116-77-8 Usage
Description
S-Sulindac Sulfoxide, also known as (S)-Sulindac, is the S-epimer metabolite of Sulindac (S699215). It is a pharmaceutical compound derived from the metabolism of Sulindac, which is a nonsteroidal anti-inflammatory drug (NSAID). S-Sulindac Sulfoxide has been found to have increased activity in the P450 system compared to its R-epimer counterpart, making it a promising candidate for various applications in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
S-Sulindac Sulfoxide is used as an active metabolite for enhancing the activity of the P450 system. Its increased activity compared to (R)-Sulindac makes it a valuable compound in the development of new drugs and therapies.
Used in NSAID Development:
S-Sulindac Sulfoxide is used as a key component in the development of nonsteroidal anti-inflammatory drugs (NSAIDs). Its ability to increase the activity of the P450 system, which is involved in the metabolism of various drugs, makes it a potential candidate for improving the efficacy and safety of NSAIDs.
Used in Enzyme Research:
S-Sulindac Sulfoxide is used as a research tool for studying the function and regulation of enzymes, particularly those involved in the P450 system. Understanding the interactions between S-Sulindac Sulfoxide and these enzymes can provide valuable insights into the development of new drugs and therapies.
Used in Drug Metabolism Studies:
S-Sulindac Sulfoxide is used as a model compound in drug metabolism studies. Its metabolism and interactions with the P450 system can help researchers understand the factors that influence drug metabolism and develop strategies to optimize drug efficacy and minimize side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 149116-77-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,9,1,1 and 6 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 149116-77:
(8*1)+(7*4)+(6*9)+(5*1)+(4*1)+(3*6)+(2*7)+(1*7)=138
138 % 10 = 8
So 149116-77-8 is a valid CAS Registry Number.
149116-77-8Relevant articles and documents
Catalyst-free visible light-mediated selective oxidation of sulfides into sulfoxides under clean conditions
Fan, Qiangwen,Zhu, Longwei,Li, Xuhuai,Ren, Huijun,Wu, Guorong,Zhu, Haibo,Sun, Wuji
supporting information, p. 7945 - 7949 (2021/11/01)
A facile and efficient visible-light-mediated method for directly converting sulfides into sulfoxides under clean conditions without using any photocatalysts is reported. This method exhibited favourable compatibility with functional groups and afforded a series of sulfoxides with high selectivity and yields. Moreover, in order to shed more light on such a transformation, detailed mechanism studies were carried out both experimentally and theoretically. The readily accessible, low-cost and eco-friendly nature of the developed method will endow it with attractive applications in chemical synthesis.
Process for the preparation of organic compounds containing a sulfinyl or sulfonyl group
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Page 3, (2008/06/13)
A process for the oxidation of thioethers to sulfoxides or sulfones or for the oxidation of sulfoxides to sulfones by treatment of thioethers or sulfoxides with an oxidizing amount of ε-phthalimidoperhexanoic acid is particularly useful for the preparation of compounds of industrial interest, in particular pharmaceuticals for human or veterinary use.
