149140-54-5 Usage
Description
(3R-cis)-4-Phenyl-3-[(triethylsilyl)oxy]-2-azetidinone, also known as (3R,4S)-3-[(Triethylsilyl)oxy]-4-phenyl-2-azetidinone (CAS# 149140-54-5), is a white solid compound that is useful in organic synthesis. It is characterized by its unique molecular structure, which includes a phenyl group and a triethylsilyl group, making it a versatile building block for the creation of various organic compounds.
Uses
Used in Organic Synthesis:
(3R-cis)-4-Phenyl-3-[(triethylsilyl)oxy]-2-azetidinone is used as a synthetic building block for the development of new organic compounds. Its unique structure allows for the formation of a wide range of molecules with diverse applications in various industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (3R-cis)-4-Phenyl-3-[(triethylsilyl)oxy]-2-azetidinone is used as a key intermediate in the synthesis of various drugs. Its ability to form a variety of organic compounds makes it a valuable asset in the development of new medications with improved efficacy and reduced side effects.
Used in Chemical Research:
(3R-cis)-4-Phenyl-3-[(triethylsilyl)oxy]-2-azetidinone is also used in chemical research as a model compound to study various reaction mechanisms and to develop new synthetic methods. Its unique structure provides researchers with valuable insights into the behavior of similar compounds and helps in the design of more efficient and selective synthetic routes.
Used in Material Science:
In the field of material science, (3R-cis)-4-Phenyl-3-[(triethylsilyl)oxy]-2-azetidinone can be used as a component in the development of new materials with specific properties. Its versatility in forming different organic compounds allows for the creation of materials with tailored characteristics, such as improved mechanical strength, thermal stability, or chemical resistance.
Check Digit Verification of cas no
The CAS Registry Mumber 149140-54-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,9,1,4 and 0 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 149140-54:
(8*1)+(7*4)+(6*9)+(5*1)+(4*4)+(3*0)+(2*5)+(1*4)=125
125 % 10 = 5
So 149140-54-5 is a valid CAS Registry Number.
InChI:InChI=1/C15H23NO2Si/c1-4-19(5-2,6-3)18-14-13(16-15(14)17)12-10-8-7-9-11-12/h7-11,13-14H,4-6H2,1-3H3,(H,16,17)/t13-,14+/m0/s1
149140-54-5Relevant articles and documents
Syntheses and biological evaluation of C-30-N-acyl modified taxane analogues from 1-deoxybaccatin-VI
Li, Qing-Feng,Lin, Hai-Xia,Cui, Yong-Mei,Xu, Pei-Pei
, p. 97 - 105 (2015)
A series of side-chain modified taxane analogues were synthesized and their in vitro anticancer activities against four human cancer cell lines: MDA-MB-231 (human breast cancer), PC-3 (human prostatic cancer), HepG2 and H460 (human hepatoma) were studied.
A four-membered ring taxol alkane side chain compound preparation method
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Page/Page column 4-8, (2017/11/16)
The invention relates to a preparation method of a four-membered ring taxane side chain compound, and belongs to the field of synthesis of medicines. The four-membered ring taxane side chain compound as shown in the formula I is prepared from a compound as shown in the formula II. The preparation method overcomes the defects of being low in reaction yield and complicated in postprocessing, and needing column chromatography to obtain a purified product in the industrial production in the prior art, and has the advantages of simple equipment, easiness in operation, higher yield, and easiness in industrial production.
Semisynthesis of flexible 5,7-dideoxypaclitaxel derivatives from Taxine B
Beusker, Patrick H.,Veldhuis, Harald,Van Den Bossche, Bianca A. C.,Scheeren, Hans W.
, p. 1761 - 1768 (2007/10/03)
Two new 5,7-dideoxypaclitaxel derivatives with flexible C-rings have been prepared starting from Taxine B, an alkaloid isolated from the leaves of Taxus baccata. Both derivatives lack the oxetane ring present in the antitumor agent paclitaxel, but possess an oxygenated 4β-substituent as a substitute for the oxetane ring oxygen atom. These derivatives provide additional information about the importance of this oxygen atom for cytotoxic activity.
