14929-11-4

Basic information

• Product Name: simfibrate
• Synonyms: simfibrate;1,3-Propanediol bis[2-(4-chlorophenoxy)-2-methylpropionate];Bis[2-(4-chlorophenoxy)-2-methylpropanoic acid] 1,3-propanediyl;Cholesolvin;CLY-503;Sinfibrate;Propane-1,3-diyl bis(2-(4-chlorophenoxy)-2-methylpropanoate)
• CAS NO: 14929-11-4
• Molecular Formula: C₂₃H₂₆Cl₂O₆
• Molecular Weight: 469.358
• EINECS: 238-998-7
• Mol File: 14929-11-4.mol
• Article Data: 0

Chemical Properties

• Melting Point: 51-53°
• Boiling Point: bp0.03 197-200°; bp0.15 220-230°
• Flash Point: 178.3°C
• Appearance: /
• Density: 1.2623 (estimate)
• Vapor Pressure: 2.85E-12mmHg at 25°C
• Refractive Index: 1.541
• CAS DataBase Reference: simfibrate(CAS DataBase Reference)
• NIST Chemistry Reference: simfibrate(14929-11-4)
• EPA Substance Registry System: simfibrate(14929-11-4)

Safety Data

• Hazardous Substances Data: 14929-11-4(Hazardous Substances Data)

Usage

Originator

Cholesorbin,Takeda,Japan,1971

Manufacturing Process

A mixture of 22 grams of α-(p-chlorophenoxy)isobutyric acid, 3.8 grams of 1,3-propanediol, 0.5 gram of p-toluenesulfonic acid and 150 ml of xylene was refluxed. When the theoretically calculated amount of water had been removed, the xylene solution was washed with dilute aqueous sodium bicarbonate and then the xylene was distilled off. The residue was distilled under reduced pressure to give 11 grams (47% yield) of 1,3-propanediol bis[α-(p-chlorophenoxy)isobutyrate] boiling at 197° to 200°C/0.03 mm Hg.

Therapeutic Function

Antihyperlipidemic

InChI:InChI=1/C23H26Cl2O6/c1-22(2,30-18-10-6-16(24)7-11-18)20(26)28-14-5-15-29-21(27)23(3,4)31-19-12-8-17(25)9-13-19/h6-13H,5,14-15H2,1-4H3