1493694-70-4

Basic information

• Product Name: UNC2250
• Synonyms: UNC2250;trans-4-[[2-(Butylamino)-5-[5-(4-morpholinylmethyl)-2-pyridinyl]-4-pyrimidinyl]amino]cyclohexanol;(1r,4r)-4-((2-(butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol;trans-4-[[2-(Butylamino)-5-[5-(4-morpholinylmethyl)-2-pyridinyl]-4-pyrimidinyl]amino]cyclohexanol UNC2250;UNC2250(UNC 2250)
• CAS NO: 1493694-70-4
• Molecular Formula: C24H36N6O2
• Molecular Weight: 440.58164
• Product Categories: Inhibitors
• Mol File: 1493694-70-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 657.4±65.0 °C(Predicted)
• Appearance: /
• Density: 1.224±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly, Heated), Ethyl Acetate (Slightly, Heated), Methanol (Sligh
• PKA: 15.02±0.40(Predicted)
• CAS DataBase Reference: UNC2250(CAS DataBase Reference)
• NIST Chemistry Reference: UNC2250(1493694-70-4)
• EPA Substance Registry System: UNC2250(1493694-70-4)

Safety Data

• Hazardous Substances Data: 1493694-70-4(Hazardous Substances Data)

Usage

Description

UNC2250 is a potent inhibitor of Mer kinase activity, which is a member of the TAM family of receptor tyrosine kinases. It effectively blocks the steady-state phosphorylation of endogenous Mer in cells and is selective for Mer over other tyrosine and serine-threonine kinases, such as Tyro3 and Axl. UNC2250 also inhibits ligand-dependent phosphorylation of a chimeric EGFR-Mer protein and demonstrates good pharmacokinetic properties in mice upon intravenous or oral administration.

Uses

Used in Pharmaceutical Industry:
UNC2250 is used as an inhibitor of Mer kinase activity for its potential role in treating various types of cancer. By blocking the phosphorylation of Mer, it can potentially disrupt cancer cell signaling and growth.
Used in Cancer Research:
In cancer research, UNC2250 is used as a tool to study the role of Mer kinase in tumor growth and progression. It can help researchers understand the underlying mechanisms of Mer kinase in different types of cancer and identify potential therapeutic targets.
Used in Drug Development:
UNC2250 is used in the development of novel drugs targeting Mer kinase, which may have applications in the treatment of various cancers. Its selectivity and potency make it a promising candidate for further research and development in the pharmaceutical industry.
Used in Preclinical Studies:
In preclinical studies, UNC2250 is used to evaluate its efficacy and safety in animal models of cancer. These studies can provide valuable information on the potential therapeutic benefits and side effects of UNC2250 before it proceeds to clinical trials in humans.

references

[1] zhang w, zhang d, stashko m a, et al. pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new mer kinase inhibitors. journal of medicinal chemistry, 2013, 56(23): 9683-9692.