149597-92-2

Basic information

• Product Name: 3,3-Diphenyl-L-alanine
• Synonyms: BETA-PHENYL-L-PHENYLALANINE;H-DPH-OH;H-ALA(3,3-DIPHENYL)-OH;H-(3-PHENYL)PHE-OH;L-3,3-DIPHENYLALANINE;3,3-DIPHENYL-L-ALANINE;(S)-DIPHENYLALANINE;(S)-2-AMINO-3,3-DIPHENYL-PROPIONIC ACID
• CAS NO: 149597-92-2
• Molecular Formula: C₁₅H₁₅NO₂
• Molecular Weight: 241.29
• Product Categories: Amino Acids;Phenylalanine analogs and other aromatic alpha amino acids;Amino Acid Derivatives;Peptide;a-amino;unnatural amino acids
• Mol File: 149597-92-2.mol
• Article Data: 7

Chemical Properties

• Melting Point: 234-240 °C
• Boiling Point: 389.2 °C at 760 mmHg
• Flash Point: 189.2 °C
• Appearance: /
• Density: 1.198 g/cm³
• Storage Temp.: Store at 0°C
• PKA: 2.11±0.10(Predicted)
• CAS DataBase Reference: 3,3-Diphenyl-L-alanine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3-Diphenyl-L-alanine(149597-92-2)
• EPA Substance Registry System: 3,3-Diphenyl-L-alanine(149597-92-2)

Safety Data

• Hazard Codes: T,Xi
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 2
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 149597-92-2(Hazardous Substances Data)

Usage

Description

3,3-Diphenyl-L-alanine is an organic compound that serves as an intermediate in the synthesis of various organic chemicals. It is characterized by its white powder form and is known for its role in the production of different compounds.

Uses

Used in Organic Chemical Synthesis:
3,3-Diphenyl-L-alanine is used as an organic chemical synthesis intermediate for the production of various compounds. Its unique structure allows it to be a valuable building block in the creation of a wide range of organic molecules, contributing to the development of new materials and pharmaceuticals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3,3-Diphenyl-L-alanine is used as a key component in the synthesis of certain drugs. Its incorporation into the molecular structure of these drugs can enhance their efficacy, selectivity, and overall performance in treating various medical conditions.
Used in Research and Development:
3,3-Diphenyl-L-alanine is also utilized in research and development settings, where it aids scientists in understanding the properties and behavior of different organic compounds. Its use in this context can lead to the discovery of new chemical reactions and the development of innovative synthetic methods.
Overall, 3,3-Diphenyl-L-alanine is a versatile compound with applications in various industries, including organic chemical synthesis, pharmaceuticals, and research and development. Its unique properties and potential for use in the creation of new compounds make it an important tool in the field of chemistry.

Upstream product

• 90-99-3 diphenylchloromethane 
• 62653-26-3 2-amino-3,3-diphenylpropionic acid 
• 1004755-24-1 1,1-dimethylethyl (2R)-(2,6-dichlorophenyl)-(4S)-(diphenylmethyl)-5-oxo-3-((1'R)-phenylethyl)tetrahydro-1H-1-imidazolecarboxylate 
• 177583-36-7 methyl 2-(tert-butoxycarbonylamino)-3,3-diphenylpropanoate 
• 776-74-9 Bromodiphenylmethane 
• 138566-19-5 N-(diphenylmethylene)-L-3,3-diphenylalaninesultam 
• 138566-20-8 L-3,3-diphenylalaninesultam hydrochloride 

Downstream Products

• 149597-89-7 (2S)-2-acetylamino-3,3-diphenyl-propionic acid 
• 1374041-09-4 methyl [(2S)-1-({2-[(3S)-3-[(tert-butoxycarbonyl)amino]-4-{[tert-butyl(diphenyl)silyl]oxy}butyl]phenyl}amino)-1-oxo-3,3-diphenylpropan-2-yl]carbamate 
• 1374041-10-7 N-{2-[(3S)-3-amino-4-{[tert-butyl(diphenyl)silyl]oxy}butyl]phenyl}-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide 
• 1374041-11-8 N-{2-[(3S)-4-{[tert-butyl(diphenyl)silyl]oxy}-3-{[(4-nitrophenyl)sulfonyl]amino}butyl]phenyl}-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide 
• 1374041-12-9 N-{2-[(3S)-4-{[tert-butyl(diphenyl)silyl]oxy}-3-{(3-methylbutyl)[(4-nitrophenyl)sulfonyl]amino}butyl]phenyl}-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide 
• 1374041-13-0 N-{2-[(3S)-4-hydroxy-3-{(3-methylbutyl)[(4-nitrophenyl)sulfonyl]amino}butyl]phenyl}-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide 
• 1374040-71-7 N-{2-[(3S)-3-{[(4-aminophenyl)sulfonyl](3-methylbutyl)amino}-4-hydroxybutyl]phenyl}-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide 
• 1384275-60-8 (S)-2-((S)-1-((S)-2-((S)-2-((tert-butoxycarbonyl)(methyl)amino)propanamido)-2-cyclohexylacetyl)pyrrolidin-2-carboxamido)-3,3-diphenylpropanoic acid 
• 1384275-58-4 benzyl (S)-2-((S)-1-((S)-2-((S)-2-((tert-butoxycarbonyl)(methyl)amino)propanamido)-2-cyclohexylacetyl)pyrrolidine-2-carboxamido)-3,3-diphenylpropanoate 
• 1384275-56-2 benzyl (S)-2-((S)-1-((S)-2-((tert-butoxycarbonyl)amino)-2-cyclohexylacetyl)pyrrolidine-2-carboxamido)-3,3-diphenylpropanoate 
• 1384275-54-0 tert-butyl (S)-2-(((S)-1-(benzyloxy)-1-oxo-3,3-diphenylpropan-2-yl)carbamoyl)pyrrolidine-1-carboxylate 
• 97015-54-8 4-benzhydryl-2-phenyloxazol-5(4H)-one 
• 1562416-41-4 N-benzoyl-L-β,β-diphenylalanine methyl ester 
• 1562416-42-5 C₂₃H₂₁NO₃ 

Relevant articles and documents

Comparative studies on enantiomer resolution of α-amino acids and their esters using (18-crown-6)-tetracarboxylic acid as a chiral crown ether selector by nmr spectroscopy and high-performance liquid chromatography

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NOVEL IMIDAZOLIDINONE DERIVATIVE, METHOD OF PRODUCING THE SAME AND METHOD OF PRODUCING OPTICALLY ACTIVE AMINO ACID

The objective of the present invention is to provide an optically active imidazolidinone derivative widely usable for synthesizing an optically active amino acid, a method of easily producing the derivative, and a method of easily producing an optically active amino acid by using the derivative. The objective can be achieved by producing an optically active amino acid using a novel optically active imidazolidinone derivative represented by a general formula (3) and the like. According to the method of the present invention, an optically active imidazolidinone derivative can be obtained by preferential crystallization from a mixture of isomers of the imidazolidinone derivative. Therefore, an optically active amino acid can be easily and stereoselectively produced without cumbersome procedures required for the conventional methods, such as resolution of diastereomers, synthesis from an optically active amino acid and resolution of isomers by silica gel column cromatography.

Synthesis of both enantiomers of β,β-diphenyl-α-alanine (Dip) from glycine using (S)- or (R)-2-[(N-benzylprolyl)amino] benzophenone as a reusable chiral auxiliary

Preparative syntheses of enantiopure (S)- and (R)-Dip by α-C-alkylation with Ph2CHX (X=Cl or Br) of the glycine moiety in a Ni(II) Schiff's base complex 1 derived from glycine and (S)- or (R)-[(N-benzylprolyl)amino]benzophenone (BPB) is described. The diastereoselectivity of the alkylation with PhCH2Br in DMF in the presence of NaOH is both kinetically and thermodynamically controlled.