149709-60-4Relevant articles and documents
Preparation method of sacubitril intermediate
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, (2021/07/21)
The invention provides a preparation method of a sacubitril intermediate. According to the method, 2-bromopropionic acid is used as an initial raw material and reacts with three-level silicon halide under the catalytic action of metal to generate a silicon ylide reagent, compared with a phosphorus ylide reagent, the reaction condition is mild, a hydrogenation reduction reaction can be carried out without alkaline hydrolysis, and ethyl esterification of a SOCl2 catalytic compound III is not influenced. Meanwhile, intramolecular or intermolecular polymerization impurities formed by removal of N protecting groups during ethyl esterification of the compound III can be avoided. The method has the advantages of short preparation process route, low cost, easily available raw materials, high yield and high purity, and is suitable for industrial mass production.
Preparation method for gamma-aminovalerate derivatives
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Paragraph 0005; 0020; 0025; 0030, (2017/06/02)
The invention discloses a preparation method for gamma-aminovalerate derivatives. The method comprises the steps of reduction, oxidization, Wittig reaction and hydrogenation reduction with a starting material of N-((tert-butoxycarbonyl)amino-4,4-biphenyl-R-propanoate. The method has the advantages that the process route is short; chiral impurities are reduced by fixing a chiral center in the raw material; oxidized impurities are prevented from being generated by protecting the primary amine; and by using a palladium-charcoal or ruthenium catalyst for assisting a ligand to reduce ethylenic bond, the chiral selectivity is high, the yield is high and the method is suitable for large-scale industrial production.
Novel synthesis method of key component Sacubitril of novel anti-heart-failure drug
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, (2017/04/26)
The invention discloses a novel synthesis method of key component Sacubitril of a novel anti-heart-failure drug. The method includes transforming a starting material compound 1 to a compound 2; coupling the compound 2 with (1'1)-4-biphenylmagnesium bromide to obtain a compound 3; subjecting the compound 3 to hydrolysis reaction by loading a Boc protecting group, and preparing a compound 5 by means of one-pot reaction; subjecting the compound 5 to Boc group removal and esterification reaction to obtain a compound 6, and reacting the compound 6 with succinic anhydride without separation to obtain a compound 7, namely Sacubitril, wherein the route is as following.