1498-66-4

Basic information

• Product Name: Methanediamine, 1-(4-chlorophenyl)-N,N'-bis[(4-chlorophenyl)methylene]-
• CAS NO: 1498-66-4
• Molecular Formula: C21H15Cl3N2
• Molecular Weight: 401.723
• Mol File: 1498-66-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Methanediamine, 1-(4-chlorophenyl)-N,N'-bis[(4-chlorophenyl)methylene]-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanediamine, 1-(4-chlorophenyl)-N,N'-bis[(4-chlorophenyl)methylene]-(1498-66-4)
• EPA Substance Registry System: Methanediamine, 1-(4-chlorophenyl)-N,N'-bis[(4-chlorophenyl)methylene]-(1498-66-4)

Safety Data

• Hazardous Substances Data: 1498-66-4(Hazardous Substances Data)

Upstream product

• 102852-87-9 (E)-2-(4-chlorobenzyl)-3-phenyloxaziridine 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 77737-97-4 2,4,6,8-Tetrakis-(4-chloro-phenyl)-3,7-diaza-bicyclo[3.3.1]nonan-9-one 
• 871315-39-8 ((4-Chloro-phenyl)-{[1-(4-chloro-phenyl)-meth-(E)-ylidene]-amino}-methyl)-phosphonic acid diethyl ester 
• 110480-88-1 diethyl 1-amino(p-chlorophenyl)methylphosphonate 
• 1347739-99-4 C₁₆H₁₆Cl₂NO₃P 

Relevant articles and documents

2,4,5-Tris(alkoxyaryl)imidazoline derivatives as potent scaffold for novel p53-MDM2 interaction inhibitors: Design, synthesis, and biological evaluation

Imidazoline-based small molecule inhibitors of p53-MDM2 interaction intended for the treatment of p53 wild-type tumors are the promising structures for design of anticancer drugs. Based on fragment approach we have investigated a key role of substituents

Novel α,β-unsaturated amide derivatives bearing α-amino phosphonate moiety as potential antiviral agents

Based on flexible construction and broad bioactivity of ferulic acid, a series of novel α,β-unsaturated amide derivatives bearing α-aminophosphonate moiety were designed, synthesized and systematically evaluated for their antiviral activity. Bioassay results indicated that some compounds exhibited good antiviral activities against cucumber mosaic virus (CMV) and tobacco mosaic virus (TMV) in vivo. Especially, compound g18 showed excellent curative and protective activities against CMV, with half-maximal effective concentration (EC50) values of 284.67 μg/mL and 216.30 μg/mL, which were obviously superior to that of Ningnanmycin (352.08 μg/mL and 262.53 μg/mL). Preliminary structure-activity relationships (SARs) analysis revealed that the introduction of electron-withdrawing group at the 2-position or 4-position of the aromatic ring is favorable for antiviral activity. Present work provides a promising template for development of potential inhibitor of plant virus.

Synthesis and biological evaluation of novel phosphonates derivatives of as potential antitumor agents

A series of dialkyl [2-(4,6-dimethoxypyrimidin-2-yloxy)benzamido](aryl) methylphosphonates derivatives were designed and synthesized. All the new compounds were identified by elemental analysis, IR, 1H NMR, 31P NMR, and MS. Their antitumor activity against KB and CNE1 cells was examined. Some of the compounds showed potential antitumor activity, which provided some hints for further study of structure modification. In particular, the compounds 6i and 6j displayed more potent cytotoxic activities against KB in comparison with 5-FU. Copyright Taylor & Francis Group, LLC.