149949-30-4

Basic information

• Product Name: 2,6-Difluoro-3-methoxyBenzaldehyde
• Synonyms: 2,6-Difluoro-3-methoxybenzaldehyde;2,4-Difluoro-3-formylanisole;2,4-Difluoro-3-formylanisole, 2,6-Difluoro-m-anisaldehyde
• CAS NO: 149949-30-4
• Molecular Formula: C₈H₆F₂O₂
• Molecular Weight: 172.13
• Mol File: 149949-30-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 247°Cat760mmHg
• Flash Point: 100.3°C
• Appearance: /
• Density: 1.289g/cm³
• Vapor Pressure: 0.0262mmHg at 25°C
• Refractive Index: 1.506
• Storage Temp.: 2-8°C
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2,6-Difluoro-3-methoxyBenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Difluoro-3-methoxyBenzaldehyde(149949-30-4)
• EPA Substance Registry System: 2,6-Difluoro-3-methoxyBenzaldehyde(149949-30-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 149949-30-4(Hazardous Substances Data)

Usage

General Description

2,6-Difluoro-3-methoxyBenzaldehyde is a chemical compound that belongs to the class of organic compounds known as difluorobenzenes. It's characterized by the presence of two fluorine atoms attached to a benzene ring. In its structure, the benzene ring is further substituted with a methoxy group and an aldehyde group. The presence of these groups lends it certain unique chemical properties. 2,6-Difluoro-3-methoxyBenzaldehyde plays a significant role in various chemical reactions, acting as a versatile building block in the synthesis of various organic compounds. Its physical characteristics and properties like molecular weight, density, boiling and melting points depend on the conditions such as pressure and temperature. Always proper safety measures should be taken while dealing with it due to its possibly harmful effects.

InChI:InChI=1/C8H6F2O2/c1-12-7-3-2-6(9)5(4-11)8(7)10/h2-4H,1H3

Upstream product

• 2591-86-8 N-Formylpiperidine 
• 452-10-8 2,4-difluoro-1-methoxybenzene 
• 68-12-2 N,N-dimethyl-formamide 
• 367-27-1 2,4-difluorophenol 

Downstream Products

• 1193512-04-7 2,6-difluoro-α-[(4-fluorophenyl)amino]-3-methoxybenzeneacetonitrile 
• 1193351-06-2 2,4-dichloro-1-(4-chlorophenyl)-5-(2,6-difluoro-3-methoxyphenyl)-1H-imidazole 
• 1193348-78-5 4-chloro-1-(4-chlorophenyl)-5-(2,6-difluoro-3-methoxyphenyl)-1H-imidazole 
• 886498-45-9 (2,6-difluoro-3-methoxyphenyl)methanol 
• 1453211-52-3 2-ethynyl-1,3-difluoro-4-methoxybenzene 
• 1193353-33-1 5-(2,6-difluoro-3-methoxyphenyl)-1-(4-fluorophenyl)-2,4-dimethyl-1H-imidazole 
• 1193352-82-7 2,4-dibromo-5-(2,6-difluoro-3-methoxyphenyl)-1-(4-fluorophenyl)-1H-imidazole 
• 1193352-37-2 4-bromo-5-(2,6-difluoro-3-methoxyphenyl)-1-(4-fluorophenyl)-1H-imidazole 
• 149489-26-9 2-(2,6-difluoro-3-methoxyphenyl)ethyl-amine 

Relevant articles and documents

Phenethylthiazolylthiourea (PETT) compounds as a new class of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs

Phenylethylthiazolylthiourea (PETT) derivatives have been identified as a new series of nonnucleoside inhibitors of HIV-1 RT. Structure-activity relationship studies of this class of compounds resulted in the identification of N-[2-(2-pyridyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea hydrochloride (trovirdine; LY300046.HCl) as a highly potent anti-HIV-1 agent. Trovirdine is currently in phase one clinical trials for potential use in the treatment of AIDS. Extension of these structure-activity relationship studies to identify additional compounds in this series with improved properties is ongoing. A part of this work is described here. Replacement of the two aromatic moleties of the PETT compounds by various substituted or unsubstituted heteroaromatic rings was investigated. In addition, the effects of multiple substitution in the phenyl ring were also studied. The antiviral activities were determined on wild-type and constructed mutants of HIV-1 RT and on wild-type HIV-1 and mutant viruses derived thereof, Ile100 and Cys181, in cell culture assays. Some selected compounds were determined on double- mutant viruses, HIV-1 (Ile100/Asn103) and HIV-1 (Ile100/Cys181). A number of highly potent analogs were synthesized. These compounds displayed IC50's against wild-type RT between 0.6 and 5 nM. In cell culture, these agents inhibited wild-type HIV-1 with ED50's between I and 5 nM in MT-4 cells. In addition, these derivatives inhibited mutant HIV-1 RT (Ile 100) with IC50's between 20 and 50 nM and mutant HIV-1 RT (Cys 181) with IC50's between 4 and 10 nM, and in cell culture they inhibited mutant HIV-1 (Ile100) with ED50's between 9 and 100 nM and mutant HIV-1 (Cys181) with ED50's between 3 and 20 nM.