14996-79-3Relevant articles and documents
Catalytic diazoalkane-carbonyl homologation: Synthesis of 2,2-diphenylcycloheptanone and other quaternary or tertiary arylalkanones and spirocycles by ring expansion
Burman, Jacob S.,Kingsbury, Jason S.,Rendina, Victor L.,Smolarski, Brittany A.
, p. 343 - 365 (2021/11/08)
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I(III)-catalyzed oxidative cyclization - Migration tandem reactions of unactivated anilines
Deng, Tianning,Shi, Emily,Thomas, Elana,Driver, Tom G.
supporting information, p. 9102 - 9106 (2020/11/13)
An I(III)-catalyzed oxidative cyclization-migration tandem reaction using Selectfluor as the oxidant was developed that converts unactivated anilines into 3H-indoles is reported herein. The reaction requires as little as 1 mol % of the iodocatalyst and is mild, tolerating pyridine and thiophene functional groups, and the dependence of the diastereoselectivity of the process on the identity of the iodoarene or iodoalkane precatalyst suggests that the catalyst is present for the stereochemical determining C-N bond forming step.
Highly efficient and enantioselective α-arylation of cycloalkanones by scandium-catalyzed diazoalkane-carbonyl homologation
Rendina, Victor L.,Kaplan, Hilan Z.,Kingsbury, Jason S.
experimental part, p. 686 - 693 (2012/04/04)
Functionalized α-tertiary and -quaternary 2-arylcycloalkanones are rapidly accessed by scandium(III) triflate-catalyzed diazo-alkane-carbonyl homologations. Recent developments have allowed for carbon insertion reactions to be performed with catalyst loadings as low as 0.5 mol% on scales up to 5 mmol. Pairing readily available bis- and tris(oxazoline) based ligands with scandium triflate allows access to arylated medium ring carbocycles with enantioselectivities up to 98:2 er and >98% yield. The formal C-C insertion of aryldiazo-methanes into unsubstituted cycloalkanones provides a single-step solution to the ongoing challenge of α-arylation. Georg Thieme Verlag Stuttgart · New York.
