150-83-4 Usage
Description
DL-3-HYDROXYBUTYRIC ACID SODIUM SALT, also known as (±)-Sodium 3-hydroxybutyrate, is an organic sodium salt derived from the replacement of the proton from the carboxy group of 3-hydroxybutyric acid by a sodium ion. It is a white crystalline powder and is a key intermediate in the biosynthesis and metabolism of fatty acids, widely found in biological systems.
Uses
Used in Pharmaceutical and Biomedical Research:
DL-3-HYDROXYBUTYRIC ACID SODIUM SALT is used as a research compound for studying its effects on various biological processes. It has been utilized in investigations related to fibroblast growth factor 21 (FGF21), which is involved in fatty acid β-oxidation in the liver.
Used in Analytical Chemistry:
DL-3-HYDROXYBUTYRIC ACID SODIUM SALT is used as a standard for quantifying blood plasma and milk β-hydroxybutyric acid levels, particularly in Danish Jersey cows. This application aids in understanding the metabolic health and performance of the animals.
Used in Epilepsy Research:
DL-3-HYDROXYBUTYRIC ACID SODIUM SALT is used as an experimental compound to investigate its potential anticonvulsant effects in epilepsy-induced rats, contributing to the development of new treatments for seizure disorders.
Used in Dairy Industry:
In the dairy industry, DL-3-HYDROXYBUTYRIC ACID SODIUM SALT is used to induce hyperketonemia in Holstein dairy cows. This process can help improve the overall health and productivity of the animals, leading to better milk quality and yield.
Used in Polymer Science:
DL-3-HYDROXYBUTYRIC ACID SODIUM SALT may be used in the preparation of poly(3-hydroxybutyrate), a biodegradable polymer with potential applications in various industries, including packaging and agriculture.
Biological Functions
Neuroprotective compound in experimental models of neurodegenerative diseases. Shown to be oxidized as an energetic substrate in the brain during starvation. May inhibit brain glucose oxidation, which may account for the suppression of hepatic glucose production observed after administration of ketone bodies in humans.
Biological Activity
β-Hydroxybutyric acid is a ketone body present in the rumen epithelium of liver cells. Its interconversion to acetoacetate influences the acid-base balance and is coupled NADH generation from (nicotinamide adenine dinucleotide) NAD+, measured fluorimetrically. A high plasma level of β-hydroxybutyric acid is implicated in diabetic ketoacidosis. It traverses the blood-brain barrier as a monocarboxylic acid. β-Hydroxybutyric acid may play a protective role in dopaminergic neurodegeneration in Parkinson′s disease model. β-Hydroxybutyric acid is a ligand for G protein-coupled receptor(GPR109A) and favors inhibition of secretion, transcription and translation of growth hormone (GH) and prolactin (PRL) gene in cow anterior pituitary cells (DCAPCs).
Biochem/physiol Actions
β-Hydroxybutyric acid is a ketone body present in the rumen epithelium of liver cells. Its interconversion to acetoacetate influences the acid-base balance and is coupled NADH generation from (nicotinamide adenine dinucleotide) NAD+, measured fluorimetrically. A high plasma level of β-hydroxybutyric acid is implicated in diabetic ketoacidosis. It traverses the blood-brain barrier as a monocarboxylic acid. β-Hydroxybutyric acid may play a protective role in dopaminergic neurodegeneration in Parkinson′s disease model. β-Hydroxybutyric acid is a ligand for G protein-coupled receptor(GPR109A) and favors inhibition of secretion, transcription and translation of growth hormone (GH) and prolactin (PRL) gene in cow anterior pituitary cells (DCAPCs).
Check Digit Verification of cas no
The CAS Registry Mumber 150-83-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,5 and 0 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 150-83:
(5*1)+(4*5)+(3*0)+(2*8)+(1*3)=44
44 % 10 = 4
So 150-83-4 is a valid CAS Registry Number.
InChI:InChI=1/C4H8O3.Na/c1-3(5)2-4(6)7;/h3,5H,2H2,1H3,(H,6,7);
150-83-4Relevant articles and documents
Catalyzed dehydrogenative coupling of primary alcohols with water, methanol, or amines
Zweifel, Theo,Naubron, Jean-Valere,Gruetzmacher, Hansjoerg
supporting information; experimental part, p. 559 - 563 (2009/04/14)
A working partnership: Metal-ligand cooperativity is responsible for the high activity of the rhodium amido complex 1 in the dehydrogenative coupling of primary alcohols with water, methanol, or amines, including ammonia (see scheme), to give carboxylic acids, methyl carboxylates, or amides, respectively. The catalysis proceeds under mild reaction conditions in the presence of a recyclable hydrogen acceptor A. The multistep mechanism was elucidated by computational methods. (Chemical Equation Presented)
