15004-38-3

Basic information

• Product Name: 1-(2-chloroethyl)-3-tricyclo[3.3.1.1~3,7~]dec-1-ylurea
• CAS NO: 15004-38-3
• Molecular Formula: C₁₃H₂₁ClN₂O
• Molecular Weight: 256.7716
• Mol File: 15004-38-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 435.8°C at 760 mmHg
• Flash Point: 217.3°C
• Density: 1.2g/cm³
• Vapor Pressure: 8.54E-08mmHg at 25°C
• Refractive Index: 1.553
• CAS DataBase Reference: 1-(2-chloroethyl)-3-tricyclo[3.3.1.1~3,7~]dec-1-ylurea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chloroethyl)-3-tricyclo[3.3.1.1~3,7~]dec-1-ylurea(15004-38-3)
• EPA Substance Registry System: 1-(2-chloroethyl)-3-tricyclo[3.3.1.1~3,7~]dec-1-ylurea(15004-38-3)

Safety Data

• Hazardous Substances Data: 15004-38-3(Hazardous Substances Data)

Usage

Description

1-(2-chloroethyl)-3-tricyclo[3.3.1.1~3,7~]dec-1-ylurea, also known as Temozolomide, is an alkylating agent derived from the tricyclo[3.3.1.1~3,7~]decane structure and is characterized by its chloroethyl and urea functional groups. It is a potent chemotherapeutic agent with a significant role in cancer treatment due to its ability to disrupt the DNA replication process in cancer cells, leading to cell death.

Uses

Used in Oncology:
Temozolomide is used as an anticancer agent for the treatment of specific types of cancer, particularly brain tumors such as glioblastoma multiforme. It is effective due to its alkylating properties, which interfere with the DNA replication process of cancer cells, ultimately causing cell death. It is often administered orally or intravenously and is commonly used in combination with other chemotherapy drugs to enhance treatment outcomes.
Used in Drug Combination Therapy:
In the pharmaceutical industry, Temozolomide is used as a component in combination therapies for cancer treatment. Its synergistic effects with other chemotherapeutic agents can improve the overall efficacy of cancer treatment regimens, making it a valuable asset in the fight against aggressive brain tumors and other malignancies.
Used in Clinical Research:
Temozolomide is also utilized in the field of clinical research as a subject of study for understanding the mechanisms of cancer cell death and the development of novel treatment strategies. Its role in cancer treatment provides valuable insights into the development of new drugs and therapies that can potentially minimize side effects and improve patient outcomes.

Upstream product

• 1943-83-5 2-chloroethyl isothiocyanate 
• 768-94-5 1-Adamantanamine 

Downstream Products

• 14039-08-8 C₁₃H₂₀FN₃O₂ 
• 14973-23-0 N-Adamantan-1-yl-N'-<2-fluor-aethyl>-harnstoff 
• 14039-10-2 C₁₃H₂₀ClN₃O₂ 

Relevant articles and documents

The synthesis of potential anticancer agents. XXXVI. N-nitrosoureas. II. Haloalkyl derivatives.

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