15020-57-2

Basic information

• Product Name: P-HYDROXY-N,N-DIMETHYLBENZENE SULFONAMIDE
• Synonyms: P-HYDROXY-N,N-DIMETHYLBENZENE SULFONAMIDE;4-Hydroxy-N,N-dimethylbenzenesulfonamide;N,N-Dimethyl-4-hydroxybenzenesulfonamide;N,N-dimethyl-4-hydroxybenzenesulphonamide
• CAS NO: 15020-57-2
• Molecular Formula: C₈H₁₁NO₃S
• Molecular Weight: 201.24
• Mol File: 15020-57-2.mol
• Article Data: 7

Chemical Properties

• Melting Point: 95 °C
• Boiling Point: 347.3°Cat760mmHg
• Flash Point: 163.9°C
• Appearance: /
• Density: 1.3156 (rough estimate)
• Vapor Pressure: 2.7E-05mmHg at 25°C
• Refractive Index: 1.5364 (estimate)
• PKA: 7.81±0.13(Predicted)
• CAS DataBase Reference: P-HYDROXY-N,N-DIMETHYLBENZENE SULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: P-HYDROXY-N,N-DIMETHYLBENZENE SULFONAMIDE(15020-57-2)
• EPA Substance Registry System: P-HYDROXY-N,N-DIMETHYLBENZENE SULFONAMIDE(15020-57-2)

Safety Data

• Hazardous Substances Data: 15020-57-2(Hazardous Substances Data)

Usage

Description

P-HYDROXY-N,N-DIMETHYLBENZENE SULFONAMIDE, also known as 4-Dimethylsulfamoylphenol, is an organic compound with the molecular formula C8H11NO2S. It is a synthetic intermediate that holds significant value in the field of pharmaceuticals and chemistry due to its versatile reactivity and potential applications.

Uses

Used in Pharmaceutical Synthesis:
P-HYDROXY-N,N-DIMETHYLBENZENE SULFONAMIDE is used as a synthetic intermediate for the development of various pharmaceutical compounds. Its unique chemical structure allows it to be a key component in the synthesis of complex molecules with potential therapeutic applications.
Used in the Synthesis of Neuropeptide Y Y2 Receptor Antagonists:
P-HYDROXY-N,N-DIMETHYLBENZENE SULFONAMIDE is used as a reagent to synthesize N-(4-ethoxyphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide derivatives. These derivatives act as neuropeptide Y Y2 receptor antagonists, which have potential applications in the treatment of various neurological and psychiatric disorders, such as obesity, anxiety, and depression.

InChI:InChI=1/C8H11NO3S/c1-9(2)13(11,12)8-5-3-7(10)4-6-8/h3-6,10H,1-2H3

Upstream product

• 7463-22-1 N,N-Dimethyl-p-chlorobenzenesulfonamide 
• 368-87-6 4-hydroxybenzene-1-sulfonyl fluoride 
• 124-40-3 dimethyl amine 
• 66950-63-8 phenyl N,N-dimethylsulfamate 
• 4025-67-6 4-hydroxybenzene-1-sulfonyl chloride 
• 825-90-1 sodium p-hydroxybenzenesulfonate 
• 59907-37-8 N,N-dimethyl-4-methoxybenzenesulfonamide 
• 383-31-3 4-fluoro-1-(N,N-dimethylaminosulfonyl)benzene 
• 79119-26-9 4-acetoxybenzenesulfonyl chloride 
• 506-59-2 N,N-dimethylammonium chloride 

Downstream Products

• 1383479-24-0 C₂₇H₃₀N₂O₅S 
• 32547-91-4 N,N-dimethyl-4-(prop-2-ynyloxy)benzenesulfonamide 
• 61712-33-2 2,6-Dibromo-N,N-dimethyl-1-phenol-4-sulfonamide, propionate 
• 1196485-25-2 4-[4-(4-dimethylsulfamoyl-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester 
• 30989-03-8 2-chloro-N,N-dimethyl-1-phenol-4-sulfonamide 
• 61712-32-1 2,6-dichloro-N,N-dimethyl-1-phenol-4-sulfonamide 
• 31972-17-5 2,6-dibromo-N,N-dimethyl-1-phenol-4-sulfonamide 
• 76472-25-8 p-(p-Guanidinobenzoyloxy)-N,N-dimethylbenzenesulfonamide methanesulfonic acid salt 
• 100245-27-0 1-(4-Methoxy-benzyl)-1H-tetrazole-5-carboxylic acid (5-dimethylsulfamoyl-2-hydroxy-phenyl)-amide 
• 100245-58-7 1H-Tetrazole-5-carboxylic acid (5-dimethylsulfamoyl-2-hydroxy-phenyl)-amide 
• 24962-75-2 3-amino-4-hydroxy-N,N-dimethylbenzenesulphonamide 
• 42247-91-6 4-hydroxy-N,N-dimethyl-3-nitrobenzenesulfonamide 
• 51005-99-3 Methoxymethyl-phosphonic acid 4-dimethylsulfamoyl-phenyl ester ethyl ester 
• 41990-33-4 Methoxymethyl-phosphonothioic acid O-(4-dimethylsulfamoyl-phenyl) ester O-methyl ester 

Relevant articles and documents

A new synthetic route to aryl hydroxysulfonamides via a novel Fries-type rearrangement of aryl N,N-dialkylsulfamates

A novel thia-Fries rearrangement of sulfamates 1 in AlCl3 giving good yields of para-2 and ortho-3 arylhydroxysulfonamides offers a new and efficient route to these sulfonamides.

INDOLE AND AZAINDOLE HALOALLYLAMINE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF

The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as i

MORPHOLINYL SUBSTITUTED [1,2,4]-TRIAZOLO[1,5-A]TRIAZINE AS ANTAGONIST

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