1504-64-9

Basic information

• Product Name: 3-(3-nitrophenyl)prop-2-en-1-ol
• Synonyms: 3-(3-nitrophenyl)prop-2-en-1-ol
• CAS NO: 1504-64-9
• Molecular Weight: 179.175
• Mol File: 1504-64-9.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: 3-(3-nitrophenyl)prop-2-en-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-nitrophenyl)prop-2-en-1-ol(1504-64-9)
• EPA Substance Registry System: 3-(3-nitrophenyl)prop-2-en-1-ol(1504-64-9)

Safety Data

• Hazardous Substances Data: 1504-64-9(Hazardous Substances Data)

Upstream product

• 5396-71-4 ethyl 3-(3-nitrophenyl)acrylate 
• 645-00-1 m-iodonitrobenzene 
• 1504-76-3 (E)-3-nitrocinnamaldehyde 
• 99-61-6 3-nitro-benzaldehyde 
• 555-68-0 (E)-3-Nitrocinnamic acid 
• 621-19-2 (E)-ethyl 3-(3-nitrophenyl)acrylate 
• 35418-05-4 (E)-3-nitrocinnamic acid chloride 
• 1664-59-1 3-(3-nitrophenyl)acrylic acid methyl ester 
• 2016-83-3 (E)-(3-chloroprop-1-enyl)-3-nitrobenzene 
• 1504-76-3 3-nitrocinnamaldehyde 

Downstream Products

• 22688-01-3 Methyl-m-nitrocynnamylether 
• 83101-13-7 3-(3-cyanophenyl)-1-propanol 
• 83101-15-9 3-(3-bromopropyl)cyanobenzene 
• 83101-17-1 γ-(3-Cyanphenyl)propylacetaminomalonsaeurediethylester 
• 83101-46-6 5-(3-Cyanphenyl)-2-tosylaminovaleriansaeureanilid 
• 83101-45-5 5-(3-Cyanphenyl)-2-tosylaminovaleriansaeuremorpholid 
• 83101-21-7 3-(4-Amino-4-carboxy-butyl)-benzoic acid; hydrochloride 
• 83101-19-3 2-Amino-5-(3-carbamoyl-phenyl)-pentanoic acid; hydrochloride 
• 83101-58-0 3-[5-Morpholin-4-yl-5-oxo-4-(toluene-4-sulfonylamino)-pentyl]-thiobenzamide 
• 83101-59-1 5-(3-Thiocarbamoyl-phenyl)-2-(toluene-4-sulfonylamino)-pentanoic acid phenylamide 
• 83101-50-2 5-(3-Cyanphenyl)-2-α-naphthylsulfonylaminovaleriansaeuremorpholid 
• 83101-54-6 5-(3-Cyanphenyl)-2-β-naphthylsulfonylaminovaleriansaeuremorpholid 
• 83101-63-7 3-[5-Morpholin-4-yl-4-(naphthalene-1-sulfonylamino)-5-oxo-pentyl]-thiobenzamide 
• 83101-67-1 3-[5-Morpholin-4-yl-4-(naphthalene-2-sulfonylamino)-5-oxo-pentyl]-thiobenzamide 

Relevant articles and documents

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Synthesis of Nitrogen-Containing Goniothalamin Analogues with Higher Cytotoxic Activity and Selectivity against Cancer Cells

Two series of racemic goniothalamin analogues displaying nitrogen-containing groups were designed and synthesized. A total of 19 novel analogues were evaluated against a panel of four different cancer cell lines, along with the normal prostate cell line PNT2 to determine their selectivity. Among them, goniothalamin chloroacrylamide 13 e displayed the lowest IC50 values for both MCF-7 (0.5 μm) and PC3 (0.3 μm) cells, about 26-fold more potent than goniothalamin (1). Besides its higher potency, compound 13 e also displayed much higher selectivity than goniothalamin. In contrast, goniothalamin isobutyramide 13 c was the most potent analogue against Caco-2 cells (IC50=0.8 μm), about 10-fold more potent and 17-fold more selective than 1. These results reveal the potential of compounds 13 c and 13 e for further in vivo studies, representing the first goniothalamin analogues with IC50 values in the low micromolar range and high selectivity against MCF-7, Caco-2, and PC3 cancer cell lines.

Novel Staphyloxanthin Inhibitors with Improved Potency against Multidrug Resistant Staphylococcus aureus

Diapophytoene desaturase (CrtN) is a potential novel target for intervening in the biosynthesis of the virulence factor staphyloxanthin. In this study, 38 1,4-benzodioxan-derived CrtN inhibitors were designed and synthesized to overwhelm the defects of leading compound 4a. Derivative 47 displayed superior pigment inhibitory activity, better hERG inhibitory properties and water solubility, and significantly sensitized MRSA strains to immune clearance in vitro. Notably, 47 displayed excellent efficacy against pigmented S. aureus Newman, Mu50 (vancomycin-intermediate MRSA, VISA), and NRS271 (linezolid-resistant MRSA, LRSA) comparable to that of linezolid and vancomycin in vivo.