150529-93-4 Usage
Description
(R,R)-2,2'-(DIMETHYLMETHYLENE)BIS(4-PHENYL-2-OXAZOLINE), also known as (+)-2,2′-Isopropylidenebis[(4R)-4-phenyl-2-oxazoline], is a chiral ligand that plays a crucial role in asymmetric catalysis. It is a low melting solid or liquid, which makes it suitable for various chemical reactions.
Uses
Used in Chemical Synthesis:
(R,R)-2,2'-(DIMETHYLMETHYLENE)BIS(4-PHENYL-2-OXAZOLINE) is used as a chiral ligand for the asymmetric cyclopropanation reaction of phenyliodonium ylides with alkenes. This reaction is essential for the formation of cyclopropane α-amino acid esters, which are vital components in the synthesis of various pharmaceuticals and biologically active compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (R,R)-2,2'-(DIMETHYLMETHYLENE)BIS(4-PHENYL-2-OXAZOLINE) is used as a catalyst to facilitate the production of enantiomerically pure compounds. These compounds are crucial in the development of drugs with improved efficacy and reduced side effects, as they can selectively target specific biological receptors.
Used in Research and Development:
(R,R)-2,2'-(DIMETHYLMETHYLENE)BIS(4-PHENYL-2-OXAZOLINE) is also used in research and development for the study of asymmetric catalysis and the development of new synthetic methods. Its unique properties make it an invaluable tool for chemists working on the design and synthesis of complex molecules.
Used in Material Science:
In the field of material science, (R,R)-2,2'-(DIMETHYLMETHYLENE)BIS(4-PHENYL-2-OXAZOLINE) can be used as a chiral dopant to induce optical activity in various materials, leading to potential applications in the development of advanced materials with unique properties, such as chiral liquid crystals and optically active polymers.
Check Digit Verification of cas no
The CAS Registry Mumber 150529-93-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,0,5,2 and 9 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 150529-93:
(8*1)+(7*5)+(6*0)+(5*5)+(4*2)+(3*9)+(2*9)+(1*3)=124
124 % 10 = 4
So 150529-93-4 is a valid CAS Registry Number.
150529-93-4Relevant articles and documents
Studies on a catalytic version of the Matteson asymmetric homologation reaction
Smith, Keith,Saleh, Basil A.,Alshammari, Mohammed B.,El-Hiti, Gamal A.,Elliott, Mark C.
supporting information, p. 4279 - 4284 (2021/05/31)
Studies of a catalytic asymmetric version of the Matteson reaction between dichloromethylboronates and organolithium reagents have been undertaken. From several different chiral catalytic systems studied, only one based on a mannitol derivative has given substantial asymmetric induction close to that previously achieved with a bis(oxazoline) derivative and ytterbium triflate. More detailed study of the latter reaction revealed that fresh ytterbium triflate actually reduced the level of asymmetric induction, while "aged"ytterbium triflate, or a fresh sample that had been treated with water, brought about improved induction. The implications of these findings are discussed.
An improved protocol for azole synthesis with PEG-supported Burgess reagent
Wipf, Peter,Venkatraman, Srikanth
, p. 4659 - 4662 (2007/10/03)
A polyethyleneglycol-linked version of Burgess reagent was developed and applied toward the cyclodehydration of β-hydroxy amides and thioamides. The desired oxazolines and thiazolines were obtained in high yields and excellent purities. The major advantag
