15074-53-0

Basic information

• Product Name: BIS(4-CHLOROPHENYL) PHOSPHOROCHLORIDATE
• Synonyms: BIS(4-CHLOROPHENYL) PHOSPHOROCHLORIDATE
• CAS NO: 15074-53-0
• Molecular Formula: C₁₂H₈Cl₃O₃P
• Molecular Weight: 337.52
• Mol File: 15074-53-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 423°C at 760 mmHg
• Flash Point: 333.2°C
• Appearance: /
• Density: 1.501g/cm³
• Vapor Pressure: 5.67E-07mmHg at 25°C
• Refractive Index: 1.592
• CAS DataBase Reference: BIS(4-CHLOROPHENYL) PHOSPHOROCHLORIDATE(CAS DataBase Reference)
• NIST Chemistry Reference: BIS(4-CHLOROPHENYL) PHOSPHOROCHLORIDATE(15074-53-0)
• EPA Substance Registry System: BIS(4-CHLOROPHENYL) PHOSPHOROCHLORIDATE(15074-53-0)

Safety Data

• Hazardous Substances Data: 15074-53-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H8Cl3O3P/c13-9-1-5-11(6-2-9)17-19(15,16)18-12-7-3-10(14)4-8-12/h1-8H

Upstream product

• 106-48-9 4-chloro-phenol 

Downstream Products

• 1415222-78-4 phosphoric acid bis-(4-chlorophenyl) (Z)-1-phenylpent-1-enyl ester 
• 1415222-86-4 C₂₃H₂₁Cl₂O₅P 
• 1310572-75-8 C₄₆H₆₁Cl₂O₁₂P 
• 105077-56-3 N--O-(p-nitrophenylsulphonyl)hydroxylamine 
• 105077-52-9 N--O-methylsulphonylhydroxylamine 
• 105077-58-5 N--N'-t-butylhydrazine 
• 115752-29-9 {5-[Bis-(4-chloro-phenoxy)-phosphorylamino]-1H-benzoimidazol-2-yl}-carbamic acid methyl ester 
• 116992-84-8 C₁₂H₈Cl₅NO₃P₂ 
• 92106-44-0 cyanocarbamimidoyl-phosphoramidic acid bis-(4-chloro-phenyl) ester 
• 70138-30-6 Phenyl-phosphoramidic acid bis-(4-chloro-phenyl) ester 
• 105077-49-4 N-hydroxylamine 
• 76994-72-4 Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-[6-[bis-(4-chloro-phenoxy)-phosphoryloxy]-2-(trityl-amino)-purin-9-yl]-tetrahydro-furan-3-yl ester 
• 115752-40-4 (4-Amino-3-nitro-phenyl)-phosphoramidic acid bis-(4-chloro-phenyl) ester 
• 102050-26-0 Pyrophosphorsaeure-tetrakis- 

Relevant articles and documents

Zinc-catalyzed transformation of diarylphosphoryl azides to diarylphosphate esters and amides

We have developed a facile and efficient procedure for the synthesis of diarylphosphate esters and amides. Using Zn(acac)2 as the catalyst, the reaction of diarylphosphoryl azides with aliphatic alcohols and phenols through an unusual P?N bond cleavage provided a number of diarylphosphate esters in good yields (22 examples, up to 94%). Additionally, various diarylphosphate amides were obtained from the corresponding amines in excellent yields as well (8 examples, up to 96%).

Artemisinin-derived dimer phosphate esters as potent anti-cytomegalovirus (anti-CMV) and anti-cancer agents: A structure-activity study

We recently reported the anti-cancer and anti-cytomegalovirus (CMV) activity of artemisinin-derived trioxane diphenylphosphate dimer 838. To probe the relationship between chemical structure and anti-CMV and anti-cancer activities, we now report synthesis and evaluation of a series of eight new dimer phosphate ester analogs of 838. This series of novel molecules was screened against human foreskin fibroblasts (HFFs) infected with CMV and against the human Jurkat T cell acute lymphoblastic leukemia cell line. This SAR study confirms the very high anti-CMV and anti-cancer potencies of dimer diphenyl phosphate ester 838 without its being toxic to normal cells.

SUBSTITUTED PHOSPHORYLAMIDOPHOSPHATES

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