15074-54-1 Usage
Description
2-Chlorophenyl phosphorodichloridate is an organic compound that serves as a phosphorylating reagent in the synthesis of oligonucleotides. It is a colorless liquid with significant applications in the field of molecular biology and pharmaceuticals due to its ability to facilitate the formation of crucial molecular structures.
Uses
Used in Oligonucleotide Synthesis:
2-Chlorophenyl phosphorodichloridate is used as a phosphorylating reagent for the synthesis of oligonucleotides via the triester method. This application is crucial in the development of various molecular biology techniques and the creation of synthetic genes and gene fragments.
Used in Monoand Oligonucleotide Preparation:
In the field of molecular biology, 2-chlorophenyl phosphorodichloridate is used as a reagent for the preparation of mononucleotide building blocks, which are essential components in the construction of oligonucleotides and oligonucleotide phosphorothioates. These molecules play a vital role in various research and therapeutic applications, such as gene regulation, drug discovery, and the development of novel diagnostic tools.
Used in Pharmaceutical Industry:
2-Chlorophenyl phosphorodichloridate is also utilized in the pharmaceutical industry for the synthesis of oligonucleotide-based drugs. These drugs have the potential to treat a wide range of diseases, including genetic disorders, viral infections, and cancer, by modulating gene expression or directly targeting specific molecular pathways.
Check Digit Verification of cas no
The CAS Registry Mumber 15074-54-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,0,7 and 4 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 15074-54:
(7*1)+(6*5)+(5*0)+(4*7)+(3*4)+(2*5)+(1*4)=91
91 % 10 = 1
So 15074-54-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H4Cl3O2P/c7-5-3-1-2-4-6(5)11-12(8,9)10/h1-4H
15074-54-1Relevant articles and documents
Pd(II)-catalyzed ortho-arylation of aryl phosphates and aryl hydrogen phosphates with diaryliodonium triflates
Chan, Li Yan,Cheong, Lilian,Kim, Sunggak
supporting information, p. 2186 - 2189 (2013/06/05)
Functionalized biaryl compounds were successfully synthesized using phosphates as the ortho-directing group in the Pd(II)/Pd(IV) catalytic cycle.
New phosphoroamidate compounds: Synthesis, structural characterization and studies on ZnCl2 assisted hydrolysis of the P-N bond
Malik, Payal,Chakraborty, Debashis,Ramkumar, Venkatachalam
experimental part, p. 2142 - 2148 (2011/01/08)
A variety of phosphorodiamidate compounds were synthesized from the corresponding phosphorodichloridate intermediates and phosphorus oxychloride. These were completely characterized using different spectroscopic methods and single crystal X-ray diffraction studies on one of them. Studies revealed that water in the presence of a mild Lewis acid like ZnCl2 was found to assist the hydrolysis of the P-N linkage. The proof of this concept was effectively realized through the hydrolysis of hexamethylphosphoramide.
Syntheses and spectral characterization of 2-aryloxy - 5,5′- bis(bromomethyl)-1,3,2P-dioxaphosphorinane 2-oxides
Stephen Babu,Anasuyamma,Venugopal,Naga Raju,Suresh Reddy
, p. 1248 - 1251 (2007/10/03)
2-Aryloxy-5,5′-bis(bromomethyl)-1,3,2-dioxaphosphorinane 2-oxides 3 have been synthesized by the reaction of 2,2′-bis(bromomethyl)-1,3- propanediol 1 with various arvlphosphorodichloridates 2a-h in the presence of triethylamine in dry tetrahydrofuran at room temperatuure. Their 1H, 13C, 31P NMR and mass spectral data are discussed.
