150780-67-9

Basic information

• Product Name: 5'-O-(4,4-Dimethoxytrityl)-2'-O-methyl-N-isobutyrylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
• Synonyms: 2’-O-Methy-rG(N-ibu)Phosphoramidite;N-blocked-5'-O-DMT-2'-O-Me CED guanosine phosphoramidite;5'-O-(4,4-Dimethoxytrityl)-2'-O-methyl-N-isobutyrylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite;5'-O-DMT-2'-O-Me-rG(N-iBu)-3'-CEDPA;2'-OMe-ibu-G Phosphoramidite;5'-O-DMT-2'-O-Me-G(ibu) phosporamidite;DMT-2′O-Methyl-rG(ib) Phosphoramidite;2'-O-Methyl-N2-Isobutyryl-5'-O-DMT-Guanosine-3'-CE-Phosphoramidite
• CAS NO: 150780-67-9
• Molecular Formula: C₄₅H₅₆N₇O₉P
• Molecular Weight: 869.951
• EINECS: 2017-001-1
• Mol File: 150780-67-9.mol
• Article Data: 0

Chemical Properties

• Appearance: white to off-white/
• Storage Temp.: 2-8°C
• Solubility: Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly, Sonicated)
• PKA: 9.16±0.20(Predicted)
• CAS DataBase Reference: 5'-O-(4,4-Dimethoxytrityl)-2'-O-methyl-N-isobutyrylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-(4,4-Dimethoxytrityl)-2'-O-methyl-N-isobutyrylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite(150780-67-9)
• EPA Substance Registry System: 5'-O-(4,4-Dimethoxytrityl)-2'-O-methyl-N-isobutyrylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite(150780-67-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 150780-67-9(Hazardous Substances Data)

Usage

Description

5'-O-(4,4-Dimethoxytrityl)-2'-O-methyl-N-isobutyrylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite, also known as 2''-OMe-ibu-G Phosphoramidite, is a chemical compound used in the field of molecular biology and biochemistry. It is characterized by its unique structure, which includes a 5'-O-(4,4-Dimethoxytrityl) group, a 2'-O-methyl modification, an N-isobutyrylguanosine moiety, and a 3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite group. 5'-O-(4,4-Dimethoxytrityl)-2'-O-methyl-N-isobutyrylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite plays a crucial role in the synthesis of native-like crosslinked duplex RNA through interstrand crosslinking reactions.

Uses

Used in Molecular Biology and Biochemistry:
5'-O-(4,4-Dimethoxytrityl)-2'-O-methyl-N-isobutyrylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite is used as a key building block for the synthesis of native-like crosslinked duplex RNA. The application reason is its ability to facilitate interstrand crosslinking reactions between vinylpurine on one strand and target cytosine or uracil on the opposite strand, resulting in the formation of stable and native-like duplex RNA structures.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5'-O-(4,4-Dimethoxytrityl)-2'-O-methyl-N-isobutyrylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite is used as a synthetic intermediate for the development of novel RNA-based therapeutics. The application reason is its potential to enhance the stability, specificity, and efficacy of RNA molecules, which can be utilized in the treatment of various diseases, including cancer and genetic disorders.
Used in Research and Development:
5'-O-(4,4-Dimethoxytrityl)-2'-O-methyl-N-isobutyrylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite is also used in research and development for the study of RNA structure, function, and interactions with other biomolecules. The application reason is its ability to provide insights into the molecular mechanisms underlying RNA biology and to contribute to the design of new RNA-based tools and technologies.