151-06-4

Basic information

• Product Name: chlorphentermine hydrochloride
• Synonyms: chlorphentermine hydrochloride;Benzeneethanamine, 4-chloro-.alpha.,.alpha.-dimethyl-, hydrochloride;1-(4-chlorophenyl)-2-methyl-propan-2-amine hydrochloride;1-(4-chlorophenyl)-2-methylpropan-2-amine hydrochloride;(4-Chlorophenyl)-2-Methylpropan-2-aMine Hydrochloride;4-Chloro-α,α-diMethyl-1-benzeneethanaMine Hydrochloride;4-Chloro-α,α-diMethylphenethylaMine Hydrochloride;p-Chloro-α,α-diMethylphenethylaMine Hydrochloride
• CAS NO: 151-06-4
• Molecular Formula: C₁₀H₁₄ClN*ClH
• Molecular Weight: 220.16
• EINECS: 205-782-9
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals
• Mol File: 151-06-4.mol
• Article Data: 1

Chemical Properties

• Melting Point: 234℃
• Boiling Point: 255.8°Cat760mmHg
• Flash Point: 127°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0.016mmHg at 25°C
• CAS DataBase Reference: chlorphentermine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: chlorphentermine hydrochloride(151-06-4)
• EPA Substance Registry System: chlorphentermine hydrochloride(151-06-4)

Safety Data

• Hazardous Substances Data: 151-06-4(Hazardous Substances Data)

Usage

Description

Chlorphentermine hydrochloride, also known as Pre-Sate, is a pharmaceutical compound derived from the 4-chloro derivative of the well-known appetite suppressant Phentermine. It is structurally related to amphetamine but exhibits relatively weak stimulant properties and has a low potential for abuse. Chlorphentermine hydrochloride is used as an anorectic agent, which helps in the management of obesity by suppressing appetite and promoting weight loss.

Uses

Used in Pharmaceutical Industry:
Chlorphentermine hydrochloride is used as an anorectic agent for the treatment of obesity. It works by suppressing appetite, allowing individuals to consume fewer calories and lose weight more effectively. Its relatively weak stimulant properties and low potential for abuse make it a safer alternative for weight management compared to other stimulants.
Used in Weight Management Programs:
Chlorphentermine hydrochloride is used as a component in weight management programs, where it is combined with a balanced diet and regular exercise to achieve optimal weight loss results. Its appetite-suppressing effects help individuals adhere to their diet plans and maintain a calorie deficit, leading to successful weight loss and improved overall health.
Used in Research and Development:
Chlorphentermine hydrochloride is also utilized in the research and development of new pharmaceutical compounds for the treatment of obesity and related metabolic disorders. Its unique properties and structural similarities to other stimulants make it an interesting subject for further study and potential development of more effective and safer weight loss medications.

Safety Profile

Poison by ingestion,subcutaneous, intraperitoneal, and intravenous routes.Experimental reproductive effects. When heated todecomposition it emits very toxic fumes of HCl and NOx.An anorexic agent.

InChI:InChI=1/C10H14ClN.ClH/c1-10(2,12)7-8-3-5-9(11)6-4-8;/h3-6H,7,12H2,1-2H3;1H

Upstream product

• 5468-97-3 1-(4-chlorophenyl)-2-methyl-2-propanol 
• 874-72-6 4-chlorobenzylmagnesium chloride 

Downstream Products

• 93307-18-7 N-(4-chloro-α,α-dimethylphenethyl) acrylamide 
• 51026-12-1 N-[2-(4-Chloro-phenyl)-1,1-dimethyl-ethyl]-guanidine 

Relevant articles and documents

The synthesis of new bronchodilator prodrugs

Prodrug 14 has been synthesized to investigate its lung accumulating property while prodrugs 19, 20 and 22 incorporating structural features of 14 have been prepared for evaluation as bronchodilatory agents.