151074-95-2

Basic information

• Product Name: (S)-4-Bromo-2-methyl-2-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-but-3-ynoic acid
• Synonyms: (S)-4-Bromo-2-methyl-2-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-but-3-ynoic acid
• CAS NO: 151074-95-2
• Molecular Weight: 338.158
• Mol File: 151074-95-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-4-Bromo-2-methyl-2-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-but-3-ynoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-Bromo-2-methyl-2-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-but-3-ynoic acid(151074-95-2)
• EPA Substance Registry System: (S)-4-Bromo-2-methyl-2-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-but-3-ynoic acid(151074-95-2)

Safety Data

• Hazardous Substances Data: 151074-95-2(Hazardous Substances Data)

Upstream product

• 151124-11-7 (+)-(6S,7S)-7-Methyl-7-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>-1-aza-5-oxabicyclo<4.2.0>octan-8-one 
• 151074-83-8 (+)-(2S)-Methyl 2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>-3-oxopropanoate 
• 134627-50-2 (6S,7S)-7-<(4S)-2-Oxo-4-phenyl-1,3-oxazolidin-3-yl>-1-aza-5-oxabicyclo<4.2.0>octan-8-one 
• 151074-94-1 (+)-(2S)-Methyl 4,4-dibromo-2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>-3-butenoate 

Downstream Products

• 263017-01-2 (+)-(2S)-α-Ethynylalanine 
• 16820-25-0 (+)-(2S)-α-Methyl-α-vinylglycine 

Relevant articles and documents

Asymmetric Synthesis of α-Alkyl-α-amino Acids from Chromium-Carbene-Complex-Derived β-Lactams

Optically active bicyclic β-lactam 3 was synthesized by photolysis of optically active oxazolidine carbene chromium complex 1 with oxazine 2.Conversion of the oxazolidine to the oxazolidinone gave a bicyclic β-lactam readily α-alkylated.Cleavage of the alkylated β-lactam gave optically active ester aldehyde 7, which was converted to a number of optically active α-alkyl-α-amino acids.These include (R)-α-methylserine, (S)-α-methylglutamic acid, (S)-α-methylornithine, (S)-vinylalanine, (S)-ethynylalanine, and (S)-2-methyl-2,3-diaminopropionic acid.