151091-46-2

Basic information

• Product Name: VUF 4592
• Synonyms: VUF 4592
• CAS NO: 151091-46-2
• Molecular Weight: 413.56
• Mol File: 151091-46-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: VUF 4592(CAS DataBase Reference)
• NIST Chemistry Reference: VUF 4592(151091-46-2)
• EPA Substance Registry System: VUF 4592(151091-46-2)

Safety Data

• Hazardous Substances Data: 151091-46-2(Hazardous Substances Data)

Upstream product

• 65488-05-3 4-iodobutyrophenone 
• 115-46-8 C₁₈H₂₁NO 
• 24070-52-8 4-bromo-1-phenyl-1-butanone 
• 939-52-6 4-chloro-1-phenylbutan-1-one 

Relevant articles and documents

METHODS AND COMPOSITIONS FOR TREATING INFECTION

Provided herein are compositions and methods for treating or preventing infection.

Identification of terfenadine as an inhibitor of human CD81-receptor HCV-E2 interaction: Synthesis and structure optimization

Terfenadine (4-[4-(hydroxydiphenylmethyl)-1-piperidyl]-1-(4-tert- butylphenyl)-butan-1-ol) was identified in a biological screening to be a moderate inhibitor (27 % inhibition) of the CD81-LEL-HCV-E2 interaction. To increase the observed biological activity, 63 terfenadine derivates were synthesized via microwave assisted nucleophilic substitution. The prepared compounds were tested for their inhibitory potency by means of a fluorescence labeled antibody assay using HUH7.5 cells. Distinct structure-activity relationships could be derived. Optimization was successful, leading to 3g, identfied as the most potent compound (69 % inhibition). Experiments with viral particles revealed that there might be additional HCV infection reducing mechanisms.