151140-66-8 Usage
Description
(4-AMINO-3-IODOPHENYL)-N-METHYLMETHANESULFONAMIDE, also known as 4-Amino-3-iodo-N-methylbenzenemethanesulfonamide, is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its unique molecular structure, which includes an amino group, an iodine atom, and a methanesulfonamide group, all attached to a phenyl ring. (4-AMINO-3-IODOPHENYL)-N-METHYLMETHANESULFONAMIDE plays a significant role in the development of medications targeting specific receptors in the human body.
Uses
Used in Pharmaceutical Synthesis:
(4-AMINO-3-IODOPHENYL)-N-METHYLMETHANESULFONAMIDE is used as an intermediate in the synthesis of D471500, a compound related to Sumatriptan (S810000, Succinate Salt). Sumatriptan is a serotonin 5HT1-receptor agonist, which is commonly used to treat migraines and cluster headaches. The intermediate compound aids in the production of Sumatriptan, contributing to the development of effective treatments for these conditions.
Used in the Synthesis of Impurities:
In addition to its role in synthesizing Sumatriptan, (4-AMINO-3-IODOPHENYL)-N-METHYLMETHANESULFONAMIDE is also utilized in the synthesis of D471500, which is an impurity of Sumatriptan. Understanding and controlling the presence of such impurities is essential for ensuring the safety, efficacy, and quality of the final pharmaceutical product. By incorporating this intermediate in the synthesis process, researchers can better study and manage the presence of D471500 in Sumatriptan formulations.
Check Digit Verification of cas no
The CAS Registry Mumber 151140-66-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,1,1,4 and 0 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 151140-66:
(8*1)+(7*5)+(6*1)+(5*1)+(4*4)+(3*0)+(2*6)+(1*6)=88
88 % 10 = 8
So 151140-66-8 is a valid CAS Registry Number.
151140-66-8Relevant articles and documents
INDOLYLALKYL DERIVATIVES OF PYRIMIDINYLPIPERAZINE AND METABOLITES THEREOF FOR TREATMENT OF ANXIETY, DEPRESSION, AND SEXUAL DYSFUNCTION
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, (2009/12/04)
The present invention relates to a method for alleviation, prevention, and treatment of anxiety, depression, and sexual dysfunction by administering certain indolylalkyl derivatives of pyrimidinylpiperazine or metabolites thereof. A preferred embodiment is of the following formula:
Process for large-scale production of indolyl alkyl pyrimidinyl piperazine compounds
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, (2008/06/13)
An improved, novel convergent process suitable for large scale preparation of the antimigraine agent 4-(5-methoxy-4-pyrimidinyl)-1-[3-[5-[[(methylamino)sulfonyl]methyl]-1H-indol-3-yl]propyl]piperazine (BMS 180048) and close analogs. The improved process provides efficiencies in handling, purification, and product yield and involves a novel heteroannulation reaction that provides the indole ring moiety and propylpiperazinyl-pyrimidine backbone in a single step.
INDOLYLALKYL DERIVATIVES OF PYRIMIDINYLPIPERAZINE FOR TREATING VASCULAR HEADACHE
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, (2008/06/13)
A series of novel indol-3-ylalkyl derivatives of alkoxypyrimidinylpiperazines are disclosed as Formula I. STR1 These compounds are intended to be useful agents for alleviation of vascular headache on the basis of their potent affinity and agonist activity at 5-HT1D binding sites.
