151265-36-0 Usage
Description
(16α)-21-Chloro-17-hydroxy-16-Methylpregna-1,4,9(11)-triene-3,20-dione is a chemical compound belonging to the class of steroids. It is characterized by its unique molecular structure, which includes a chloro group at the 21st position, a hydroxy group at the 17th position, and a methyl group at the 16th position. (16α)-21-Chloro-17-hydroxy-16-Methylpregna-1,4,9(11)-triene-3,20-dione plays a crucial role in the pharmaceutical industry due to its intermediate role in the synthesis of various medications.
Uses
Used in Pharmaceutical Industry:
(16α)-21-Chloro-17-hydroxy-16-Methylpregna-1,4,9(11)-triene-3,20-dione is used as an intermediate in the synthesis of Mometasone Furoate (M490000), a topical corticosteroid. It serves as a key component in the production process, enabling the creation of an anti-inflammatory agent that can be applied to treat various skin conditions, such as eczema, dermatitis, and other inflammatory skin disorders.
Application Reason:
The compound's unique structure allows it to be a vital building block in the synthesis of Mometasone Furoate, which is known for its potent anti-inflammatory properties. By acting as an intermediate, (16α)-21-Chloro-17-hydroxy-16-Methylpregna-1,4,9(11)-triene-3,20-dione contributes to the development of an effective treatment for skin inflammation and other related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 151265-36-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,1,2,6 and 5 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 151265-36:
(8*1)+(7*5)+(6*1)+(5*2)+(4*6)+(3*5)+(2*3)+(1*6)=110
110 % 10 = 0
So 151265-36-0 is a valid CAS Registry Number.
151265-36-0Relevant articles and documents
An effective method for the preparation of 21-chlorosteroids using the Vilsmeier reagent
Wuts,Cabaj,Maisto
, p. 2199 - 2211 (1993)
A simple procedure for the conversion of 21-steroidal alcohols to the corresponding 12-chlorides using the Vilsmeier reagent is described.
Preparation method of clobetasol propionate
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Paragraph 0056-0058, (2018/03/25)
The invention provides a brand new synthesis route for preparation of clobetasol propionate; adopted raw materials are cheaper and are easier to obtain, reactive raw materials are hydroxylated and then chloridized, carbonyl protection groups are removed, five-membered ring double bonds are subjected to selective oxidation and reduction, after esterification, six-membered ring double bonds are subjected to epoxidation, and then fluorination ring opening is performed to obtain the clobetasol propionate product. The reaction process is easy to operate, the yield of each step is relatively high, the purity of the obtained product is higher, the formation of by-products is effectively avoided, the production cost is reduced and industrialized production is facilitated.
17β-cyano-9α,17α-dihydroxyandrost-4-en-3-one
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, (2008/06/13)
The invention is the compound 17β-cyano-9α, 17α-dihydroxyandrost-4-en-3-one (I) which is particularly useful as an intermediate in the production of the 17α-halo silyl ethers (II).
