151409-44-8

Basic information

• Product Name: 1-[2-(3,4-Dihydroxy-phenyl)-ethyl]-4-methyl-1,4-dihydro-pyridine-3,5-dicarbaldehyde
• CAS NO: 151409-44-8
• Molecular Weight: 287.315
• Mol File: 151409-44-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-[2-(3,4-Dihydroxy-phenyl)-ethyl]-4-methyl-1,4-dihydro-pyridine-3,5-dicarbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-(3,4-Dihydroxy-phenyl)-ethyl]-4-methyl-1,4-dihydro-pyridine-3,5-dicarbaldehyde(151409-44-8)
• EPA Substance Registry System: 1-[2-(3,4-Dihydroxy-phenyl)-ethyl]-4-methyl-1,4-dihydro-pyridine-3,5-dicarbaldehyde(151409-44-8)

Safety Data

• Hazardous Substances Data: 151409-44-8(Hazardous Substances Data)

Upstream product

• 542-78-9 Malondialdehyde 
• 62-31-7 dopamine hydrochloride 
• 51-61-6 dopamine 

Relevant articles and documents

Reaction of malondialdehyde with amine neurotransmitters. Formation and oxidation chemistry of fluorescent 1,4-dihydropyridine adducts

Under physiologically relevant conditions, malondialdehyde reacts smoothly with amine neurotransmitters, i.e. dopamine, norepinephrine and serotonin, to give the fluorescent dihydropyridines 1, 4 and 5, respectively, as the relatively most abundant products. Small amounts of enaminal derivatives, such as 2 and 6, could also be obtained in the reactions with dopamine and serotonin. Oxidation of 1 with hydrogen peroxide/peroxidase leads to a complex pattern of unstable products, the major of which has been isolated and identified as the o-quinone epoxide 7. Similar oxidation of 4 and 5 affords mainly the dihydropyridine 8 and the 4,4'-biindolyl 9, respectively. These results provide new clues to the role of malondialdehyde in neuronal degeneration and lipofusion formation.