151597-71-6Relevant articles and documents
Synthesis of coumarins by ring-closing metathesis using Grubbs' catalyst
Nguyen Van, Tuyen,Debenedetti, Silvia,De Kimpe, Norbert
, p. 4199 - 4201 (2007/10/03)
A novel generally applicable synthesis of coumarins from phenolic substrates utilizing ring-closing metathesis is described. This sequence involves O-allylation of phenols followed by ortho-Claisen rearrangement, subsequent based-induced isomerization affording 2-(1-propenyl)phenols, acylation with acryloyl chloride, and finally ring-closing metathesis (RCM) with Grubbs' second generation catalyst.