1516-33-2

Basic information

• Product Name: ISOBUTYLTHIOUREA
• Synonyms: Thiourea,N-(2-Methylpropyl)-
• CAS NO: 1516-33-2
• Molecular Formula: C₅H₁₂N₂S
• Molecular Weight: 132.23
• Mol File: 1516-33-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 194.6°Cat760mmHg
• Flash Point: 71.5°C
• Appearance: /
• Density: 1.025g/cm³
• Vapor Pressure: 0.437mmHg at 25°C
• Refractive Index: 1.526
• CAS DataBase Reference: ISOBUTYLTHIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: ISOBUTYLTHIOUREA(1516-33-2)
• EPA Substance Registry System: ISOBUTYLTHIOUREA(1516-33-2)

Safety Data

• Hazardous Substances Data: 1516-33-2(Hazardous Substances Data)

Usage

General Description

ISOBUTYLTHIOUREA is a chemical compound with the molecular formula C5H12N2S. It is a derivative of thiourea and is commonly used as a reagent in organic synthesis. ISOBUTYLTHIOUREA is a colorless crystalline solid that is soluble in water and organic solvents. It is known for its ability to form complexes with metal ions, making it useful in various chemical processes such as catalysis and coordination chemistry. ISOBUTYLTHIOUREA has also been studied for its potential applications in the field of medicine, particularly in the treatment of certain diseases and as a chelating agent for metal detoxification.

InChI:InChI=1/C5H12N2S/c1-4(2)3-7-5(6)8/h4H,3H2,1-2H3,(H3,6,7,8)

Upstream product

• 591-82-2 isobutyl isothiocyanate 
• 22283-38-1 N-Benzoyl-N'-isobutylthioharnstoff 
• 117759-82-7 (1-Benzotriazol-1-yl-2-methyl-propyl)-thiourea 
• 463-71-8 thiophosgene 
• 78-81-9 isobutylamine 

Downstream Products

• 557783-72-9 N-isobutyl-4-phenyl-1,3-thiazol-2-amine 

Relevant articles and documents

SUBSTITUTED N-ALKYLPYRIMIDINONES

This invention is directed generally to substituted pyrimidinone compounds that generally inhibit p38 kinase, TNF, and/or cyclooxygenase activity. Such substituted pyrimidinone include compounds generally corresponding in structure to the following formula (I): wherein R1, R2, R3, R4A, R4B, R4C, R4D and R4E are as defined in this specification. This invention also is directed to compositions of such substituted pyrimidinones (particularly pharmaceutical compositions), intermediates for the syntheses of such substituted pyrimidinones, methods for making such substituted pyrimidinones, and methods for treating (including preventing) conditions (typically pathological conditions) associated with p38 kinase activity, TNF activity, and/or cyclooxygenase-2 activity.

THIAZOLE DERIVATIVES AND USE THEREOF

The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.

A GENERAL METHOD FOR THE N-ALKYLATION OF THIOAMIDES.

Thioamides are N-alkylated in a two-step procedure: (i) Reaction with an aldehyde and benzotriazole yields an adduct which is (ii) reduced to the N-alkylthioamide by NaBH4.