151608-48-9

Basic information

• Product Name: N-acetyl-O-[bis(benzyloxy)phosphoryl]-L-tyrosine
• Synonyms: N-acetyl-O-[bis(benzyloxy)phosphoryl]-L-tyrosine
• CAS NO: 151608-48-9
• Molecular Weight: 483.458
• Mol File: 151608-48-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-acetyl-O-[bis(benzyloxy)phosphoryl]-L-tyrosine(CAS DataBase Reference)
• NIST Chemistry Reference: N-acetyl-O-[bis(benzyloxy)phosphoryl]-L-tyrosine(151608-48-9)
• EPA Substance Registry System: N-acetyl-O-[bis(benzyloxy)phosphoryl]-L-tyrosine(151608-48-9)

Safety Data

• Hazardous Substances Data: 151608-48-9(Hazardous Substances Data)

Upstream product

• 108549-23-1 Dibenzyl N,N-diisopropylphosphoramidite 

Downstream Products

• 222737-12-4 (S)-2-{(S)-2-Acetylamino-3-[4-(bis-benzyloxy-phosphoryloxy)-phenyl]-propionylamino}-4-methyl-pentanoic acid allyl ester 

Relevant articles and documents

Development of non-peptide ligands of growth factor receptor-bound protein 2-src homology 2 domain using molecular modeling and NMR spectroscopy

We report a novel series of non-peptide ligands that inhibit the growth factor receptor-bound protein 2 (Grb2)-Src homology 2 (SH2) domain binding, designed using a combined computational and NMR-driven approach. We have identified a new lead compound, 1n (IC50 = 56 μM), which is cytotoxic in HER2-positive breast cancer cells and disrupts the interaction between HER2 and Grb2. Thus, 1n can be used as a scaffold for the development of efficient Grb2-SH2 domain binding inhibitors.