151756-51-3

Basic information

• Product Name: 5'-DMTr-N²-isobutyryl-O⁶(2-pyridyl)methyl-2'-deoxyguanosine
• CAS NO: 151756-51-3
• Molecular Weight: 730.82
• Mol File: 151756-51-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5'-DMTr-N²-isobutyryl-O⁶(2-pyridyl)methyl-2'-deoxyguanosine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-DMTr-N²-isobutyryl-O⁶(2-pyridyl)methyl-2'-deoxyguanosine(151756-51-3)
• EPA Substance Registry System: 5'-DMTr-N²-isobutyryl-O⁶(2-pyridyl)methyl-2'-deoxyguanosine(151756-51-3)

Safety Data

• Hazardous Substances Data: 151756-51-3(Hazardous Substances Data)

Upstream product

• 151780-37-9 3'-acetyl-5'-DMTr-N²-isobutyryl-O⁶(2-pyridyl)methyl-2'-deoxyguanosine 
• 586-98-1 2-Hydroxymethylpyridine 
• 68892-42-2 N-isobutyryl-2'-deoxyguanosine 
• 93130-36-0 3'-acetyl-5'-O-DMT-N²-isobutyryl-2'-deoxyguanosine 
• 961-07-9 2'-Deoxyguanosine 
• 68892-41-1 5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine 
• 129184-64-1 3',5'-bis-O-trimethylsilyl-2'-deoxyguanosine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 

Relevant articles and documents

(2-Pyridyl)methyl, a novel rwagent for O6 protection of 2'-deoxyguanosine

(2-Pyridyl)methyl group has been successfully used for the protection of O6 function in partially protected 2'-deoxyguanosine via 'Mitsunobu alkylation' to yield the fully protected monomer units for oligonucleotide synthesis.The group is easier to introduce and deprotect under milder conditions using 1,8-diazabicycloundec-7-ene (DBU) in anhyd. pyridine.A trimer d(GGA) and hexamer d(GGATCC) have been synthesized using this protected unit without any significant side reactions.